Role of Adiponectin in the Pathogenesis of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease, characterized by progressive articular damage and joint dysfunction. One of the symptoms of this disease is persistent inflammatory infiltration of the synovial membrane, the principle site of inflammation in RA....

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Bibliographic Details
Published in:International journal of molecular sciences 2020-11, Vol.21 (21), p.8265
Main Authors: Szumilas, Kamila, Szumilas, Paweł, Słuczanowska-Głąbowska, Sylwia, Zgutka, Katarzyna, Pawlik, Andrzej
Format: Article
Language:English
Subjects:
Adipokines - physiology
adiponectin
Adiponectin - metabolism
Adiponectin - physiology
adiponectin isoforms
Adipose Tissue - metabolism
Adipose Tissue - physiology
Arthritis, Rheumatoid - etiology
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - physiopathology
Humans
Inflammation - metabolism
Inflammation - pathology
Inflammation - physiopathology
Inflammation Mediators - physiology
pro-inflammation
Review
rheumatoid arthritis
Synovial Membrane - metabolism
Synovial Membrane - pathology
Synoviocytes - pathology
Synoviocytes - physiology
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Summary:Rheumatoid arthritis (RA) is a systemic chronic inflammatory autoimmune joint disease, characterized by progressive articular damage and joint dysfunction. One of the symptoms of this disease is persistent inflammatory infiltration of the synovial membrane, the principle site of inflammation in RA. In the affected conditions, the cells of the synovial membrane, fibroblast-like synoviocytes and macrophage-like synovial cells, produce enzymes degrading cartilage and underlining bone tissue, as well as cytokines increasing the infiltration of immune cells. In patients with RA, higher levels of adiponectin are measured in the serum and synovial fluid. Adiponectin, a secretory product that is mainly white adipose tissue, is a multifunctional protein with dual anti-inflammatory and pro-inflammatory properties. Several studies underline the fact that adiponectin can play an important pro-inflammatory role in the pathophysiology of RA via stimulating the secretion of inflammatory mediators. This narrative review is devoted to the presentation of recent knowledge on the role played by one of the adipokines produced by adipose tissue-adiponectin-in the pathogenesis of rheumatoid arthritis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21218265