GPETAFLR: A new anti-inflammatory peptide from Lupinus angustifolius L. protein hydrolysate

•A potential anti-inflammatory peptide was purified from lupine protein hydrolysate.•The sequence was Gly-Pro-Glu-Thr-Ala-Phe-Leu-Arg.•This octapeptide may help to prevent diseases related to chronic inflammation. An anti-inflammatory peptide was identified in lupine protein hydrolysate (LPH) obtain...

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Bibliographic Details
Published in:Journal of functional foods 2015-10, Vol.18, p.358-367
Main Authors: Millán-Linares, Mª del Carmen, Millán, Francisco, Pedroche, Justo, Yust, María del Mar
Format: Article
Language:English
Subjects:
Anti-inflammatory activity
Lupine protein hydrolysate
Octapeptide
Purification
THP-1-derived macrophages
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Summary:•A potential anti-inflammatory peptide was purified from lupine protein hydrolysate.•The sequence was Gly-Pro-Glu-Thr-Ala-Phe-Leu-Arg.•This octapeptide may help to prevent diseases related to chronic inflammation. An anti-inflammatory peptide was identified in lupine protein hydrolysate (LPH) obtained by enzymatic hydrolysis of lupine protein isolate (LPI) with Alcalase. LPH was separated in two fractions by ultrafiltration, and anti-inflammatory activity was evaluated by analysis of the expression of different cytokines in THP-1-derived macrophages by quantitative PCR (qPCR). Fraction
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2015.07.016