Today's oxidative stress markers

Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop m...

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Bibliographic Details
Published in:Medycyna pracy 2015-01, Vol.66 (3), p.393-405
Main Authors: Czerska, Marta, Mikołajewska, Karolina, Zieliński, Marek, Gromadzińska, Jolanta, Wąsowicz, Wojciech
Format: Article
Language:English
Subjects:
allantoin
Biomarkers - analysis
Free Radicals - analysis
Humans
isoprostanes
Lipid Peroxidation
metabolites of isoprostanes
Oxidation-Reduction
Oxidative Stress
oxidative stress markers
Poland
Reactive Oxygen Species - analysis
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Summary:Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously.
ISSN:0465-5893
2353-1339
DOI:10.13075/mp.5893.00137