Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage

Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation. Prevention and early intervention of inflam...

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Bibliographic Details
Published in:International journal of oral science 2021-11, Vol.13 (1), p.39-14, Article 39
Main Authors: Sun, Lizhong, He, Libang, Wu, Wei, Luo, Li, Han, Mingyue, Liu, Yifang, Shi, Shijie, Zhong, Kaijing, Yang, Jiaojiao, Li, Jiyao
Format: Article
Language:English
Subjects:
692/699/255/1318
692/699/3017/3019
Bioinformatics
Cell membranes
Cytokines
Dentistry
Escherichia coli
Fibroblasts
Humans
Inflammation
Inflammation - drug therapy
Lipopolysaccharides
Medicine
Nanoparticles
Oral and Maxillofacial Surgery
Orthopedics
Surgical Orthopedics
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Summary:Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation. Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function, but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions. In this study, we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation (early pulpitis as the model) with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo. Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide ( E. coli LPS) with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways. Moreover, nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects, attenuating inflammatory conditions in the early stage. Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage, which widens the potential cell types for inflammation regulation.
ISSN:1674-2818
2049-3169
DOI:10.1038/s41368-021-00144-2