Prevalence of Common Alleles of Some Stress Resilience Genes among Adolescents Born in Different Periods Relative to the Socioeconomic Crisis of the 1990s in Russia

• Published in: Current issues in molecular biology 2022-12, Vol.45 (1), p.51-65
• Main Authors: Mikhailova, Svetlana V, Ivanoshchuk, Dinara E, Yushkevich, Evgeniy A, Bairqdar, Ahmad, Anisimenko, Maksim S, Shcherbakova, Liliya V, Denisova, Diana V, Orlov, Pavel S
• Format: Article
• Language: English
• Subjects: COMT; DRD4; polymorphism; SLC6A4; social stress; stress resilience
• ISSN: 1467-3045; 1467-3037; 1467-3045
• DOI: 10.3390/cimb45010004

Social stress is common among people and is considered one of the causes of the declining birth rate. Predisposition to stress and stress-induced disorders is largely determined genetically. We hypothesized that due to differences in stress resistance, carriers of different genetic variants of genes associated with stress resilience and stress-induced diseases may have dissimilar numbers of offspring under conditions of long-term social stress. To test this hypothesis, a comparative analysis of frequencies of seven common polymorphic regions [exon 3 variable number of tandem repeats (VNTR) of the gene, rs4680 of , STin2 VNTR and the 5-HTTLPR (rs774676466) insertion/deletion polymorphism of , rs4570625 of , rs6265 of , and rs258747 of ] was performed on standardized groups of randomly selected adolescents born before, during, and after severe socioeconomic deprivation (the crisis of the 1990s in Russia). There were significant differences in frequencies of "long" alleles of the gene ( = 0.020, χ = 5.492) and rs4680 ( = 0.022, χ = 5.289) in the "crisis" group as compared to the combined "noncrisis" population. It is possible that the dopaminergic system had an impact on the successful adaptation of a person to social stress.