Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis

• Published in: Revista Brasileira de ginecologia e obstetrícia 2024-01, Vol.46
• Main Authors: Jacobo, Andreia, Borges, Renata Fogaça, de Souza, Carlos Augusto Bastos, Genro, Vanessa Krebs, Cunha-Filho, João Sabino
• Format: Article
• Language: English
• Subjects: Adenomyosis; Adenomyosis - metabolism; Adenomyosis - pathology; Adult; Case-Control Studies; Etiopathogenesis; Female; Humans; Immunohistochemistry; Middle Aged; OBSTETRICS & GYNECOLOGY; Original; Prospective Studies; Transforming Growth Factor beta1 - metabolism; Transforming growth factor β1
• ISSN: 0100-7203; 1806-9339; 1806-9339
• DOI: 10.61622/rbgo/2024rbgo31

To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis. A prospective design was performed including 49 patients submitted to hysterectomy. Immunohistochemistry was performed on anatomopathological samples staged in paraffin blocks from patients with and without adenomyosis. The sample contained 28 adenomyosis cases and 21 controls. Student's -test and multivariate logistic regression tests were used for statistical analysis. Associations were considered significant at < 0.05. We found no significant association between adenomyosis and: smoking ( = 0.75), miscarriage ( = 0.29), number of previous pregnancies ( = 0.85), curettage ( = 0.81), pelvic pain ( = 0.72) and myoma ( = 0.15). However, we did find a relationship between adenomyosis and abnormal uterine bleeding (AUB) ( = 0.02) and previous cesarean section ( = 0.02). The mean TGF-β1 intensity (mean ± SD) in the ectopic endometrium of women with adenomyosis showed no significant association (184.17 ± 9.4 vs.184.66 ± 16.08, = 0.86) from the topic endometrium of women without adenomyosis. TGF-β1 expression was not increased in the ectopic endometrium of women with adenomyosis.