Serum heat shock protein 70 in preeclampsia and normal pregnancy: A systematic review and meta-analysis

Preeclampsia, a severe complication of human pregnancy is one of the main causes of maternal, fetal, and neonatal morbidity and mortality with unclear pathogenesis. Heat shock protein 70 (HSP70) is one of the factors that can mediate cytoprotective, antiapoptotic, and immune regulatory effects. This...

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Bibliographic Details
Published in:International journal of reproductive biomedicine (Yazd, Iran) Iran), 2018-01, Vol.16 (1), p.1-8
Main Authors: Saghafi, Nafiseh, Pourali, Leila, Ghavami Ghanbarabadi, Vahid, Mirzamarjani, Fatemeh, Mirteimouri, Masoumeh
Format: Article
Language:English
Subjects:
Heat shock protein 70 (HSP70)
Heat shock proteins
Meta-analysis
Preeclampsia
Pregnancy
Review
Systematic review
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Summary:Preeclampsia, a severe complication of human pregnancy is one of the main causes of maternal, fetal, and neonatal morbidity and mortality with unclear pathogenesis. Heat shock protein 70 (HSP70) is one of the factors that can mediate cytoprotective, antiapoptotic, and immune regulatory effects. This meta-analysis was performed with aim to evaluate HSP70 in preeclampsia and normal pregnancy. The original publications reporting the serum HSP70 levels in preeclampsia and normal pregnancies published before November 2015 were identified by searching PubMed Central, Scopus, and ISI Web of Knowledge databases by two researchers, separately. The keywords were" preeclampsia" and "HSP70" or "Heat shock protein 70" Statistical analyses were performed using STATA software (version 11). Out of 127 studies, seven eligible case-control studies were identified which consists of 350 preeclampsia and 429 normal pregnancies. Our pooled analysis of data from 7 studies which met the inclusion criteria, provides evidence that there is a significant association between HSP70 and preeclampsia. Cochran's test results showed the heterogeneity of the studies (p
ISSN:2476-4108
2476-3772
DOI:10.29252/ijrm.16.1.1