Does the breakdown of the detoxification system for aldehydes as a result of aldose reductase upregulation lead to alcohol‐induced liver injury in humans and mice?

In the present authors’ previous article in J Diabetes Investig, the pathogenesis of NAFLD from the perspective of this pathway was discussed 11. [...]in the following, the cause of and measures against ALD from the viewpoint of AR activity in the liver are considered. ADP, adenosine diphosphate; AM...

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Bibliographic Details
Published in:Journal of diabetes investigation 2020-11, Vol.11 (6), p.1426-1430
Main Authors: Hotta, Nigishi, Kawamura, Takahiko, Umemura, Toshitaka
Format: Article
Language:English
Subjects:
Adenosine
Adenosine kinase
Adenosine triphosphate
Alcohol
Aldehyde reductase
Aldehydes
AMP
Animals
Apoptosis
Commentaries
Dehydrogenases
Detoxification
Diabetes
Diabetes mellitus
Enzymes
Fatty liver
Gene expression
Glucose
Glutathione reductase
Hyperglycemia
Inosine monophosphate
Kinases
Lipids
Liver diseases
Metabolism
Metabolites
NADH
NADP
NADPH-diaphorase
Nitric oxide
Pathogenesis
Physiology
Protein kinase
Proteins
Reactive oxygen species
Sorbitol
Steatosis
Sterols
Transcription factors
Uric acid
Xanthine oxidase
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Summary:In the present authors’ previous article in J Diabetes Investig, the pathogenesis of NAFLD from the perspective of this pathway was discussed 11. [...]in the following, the cause of and measures against ALD from the viewpoint of AR activity in the liver are considered. ADP, adenosine diphosphate; AMP, adenosine monophosphate; AMPK, adenosine monophosphate‐activated protein kinase; ATP, adenosine triphosphate; CYP2E1, cytochrome P450E1; FK, fructose kinase; GR, glutathione reductase; GSH, reduced glutathione; GSSG, glutathione disulfide; IMP, inosine monophosphate; NAD, nicotinamide adenine dinucleotide; NADH, reduced form of nicotinamide adenine dinucleotide; NADP, reduced form of nicotinamide adenine dinucleotide phosphate; NADPH, reduced form of nicotinamide adenine dinucleotide phosphate; NO, nitric oxide; NOx, reduced form of nicotinamide adenine dinucleotide oxidase; ROS, reactive oxygen species; SDH, sorbitol dehydrogenase; ROS, reactive oxygen species; SDH, sorbitol dehydrogenase; TCA, tricarboxylic acid; XO, xanthine oxidase. Furthermore, the pharmacological inhibition of AR in mice prevented alcohol‐induced hepatic steatosis, apoptosis and liver injury. [...]their study provides us a new perspective for the future from the viewpoints of both the mechanisms of and medicines for alcohol‐induced liver injury. [...]the results of their research are briefly introduced in the present article.
ISSN:2040-1116
2040-1124
DOI:10.1111/jdi.13305