An Untargeted LC–MS based approach for identification of altered metabolites in blood plasma of rheumatic heart disease patients

Rheumatic heart disease (RHD) is often considered as a disease of developing countries and India is the home of about 40% of RHD patients. Environment seems to play a major role in its causation. Since gene environment interactions can lead to alterations of various metabolic pathways, identificatio...

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Bibliographic Details
Published in:Scientific reports 2022-03, Vol.12 (1), p.5238-5238, Article 5238
Main Authors: Das, Soumi, Kumar, Yashwant, Sharma, Shruti, Ray, Ruma, Arava, Sudheer, Seth, Sandeep, Agarwal, Aman, Sharma, Gautam
Format: Article
Language:English
Subjects:
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692/4019
Biomarkers
Cardiovascular disease
Cardiovascular diseases
Chromatography, Liquid
Coronary artery disease
Developing countries
Glutamine
Heart diseases
Humanities and Social Sciences
Humans
LDCs
Metabolic pathways
Metabolism
Metabolites
Metabolomics
multidisciplinary
Plasma
Plasma - metabolism
Rheumatic heart disease
Rheumatic Heart Disease - metabolism
Science
Science (multidisciplinary)
Tandem Mass Spectrometry
Therapeutic targets
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Summary:Rheumatic heart disease (RHD) is often considered as a disease of developing countries and India is the home of about 40% of RHD patients. Environment seems to play a major role in its causation. Since gene environment interactions can lead to alterations of various metabolic pathways, identification of altered metabolites can help in understanding the various pathways leading to RHD. Blood plasma samples from 51 RHD and 49 healthy controls were collected for the study. Untargeted metabolomics approach was used to identify the metabolites that are altered in RHD patients. Data showed 25 altered metabolites among RHD patients. These altered metabolites were those involved in Purine, Glutamine, Glutamate, Pyrimidine, Arginine, Proline and Linoleic metabolism. Thus, the present study illuminates metabolic alterations among RHD patients which can help in determining the potential therapeutic targets.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-09191-z