Retrospective Chart Review on Real-World Use of Latanoprostene Bunod 0.024% in Treatment-Naïve Patients with Open-Angle Glaucoma

• Published in: Ophthalmology and therapy 2020-12, Vol.9 (4), p.1041-1053
• Main Authors: Okeke, Constance O., Burstein, Eitan S., Trubnik, Valerie, Deom, James E., Cooper, Michael S., Brinkley, Desirae A., Thimons, J. James, Kabiri, Alexander J., Gelb, Kerry M.
• Format: Article
• Language: English
• Subjects: Internal Medicine; Intraocular pressure; Latanoprostene bunod; Medicine; Medicine & Public Health; Ocular hypertension; Open-angle glaucoma; Ophthalmology; Original Research; Retrospective
• ISSN: 2193-8245; 2193-6528
• DOI: 10.1007/s40123-020-00307-0

Introduction The objective of this study was to evaluate real-world effectiveness of latanoprostene bunod (LBN) ophthalmic solution 0.024% in treatment-naïve patients newly diagnosed with open-angle glaucoma (OAG) or ocular hypertension. Methods This multicenter retrospective chart review included patients aged ≥ 18 years, with no history of medical, laser, or surgical intraocular pressure (IOP)-lowering intervention and at least two follow-up visits (spanning ≥ 2 months) following initiation of LBN treatment. Extracted data included age, sex, race, cup-to-disk ratio, central corneal thickness, IOP, visual acuity (VA), concomitant medications, and adverse events. In patients treated bilaterally, the eye with the higher baseline IOP was the study eye. Results Medical charts for 65 patients (mean [SD] age, 59 [14] years; 53.8% female) encompassing 125 eyes treated with LBN were reviewed across nine clinical sites. Mean (SD) IOP at baseline was 21.7 (5.9) mmHg. Mean days to first and second follow-up visit were 43 and 141, respectively. LBN use resulted in a mean (SD) reduction from baseline of 7.1 (4.7) and 7.3 (5.1) mmHg at the first and second follow-up visits, respectively ( P   21 mmHg ( n  = 30) at baseline were 10.0 (4.5) and 11.1 (4.6) mmHg at the first and second follow-up visits ( P