Dietary Acid Load and Its Interaction with IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) Polymorphisms on Metabolic Traits among Postmenopausal Women

The objective of this study was to explore the effects of dietary acid load (DAL) and IGF1 and IL6 gene polymorphisms and their potential diet–gene interactions on metabolic traits. A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid lo...

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Bibliographic Details
Published in:Nutrients 2021-06, Vol.13 (7), p.2161
Main Authors: Lim, Sook Yee, Chan, Yoke Mun, Ramachandran, Vasudevan, Shariff, Zalilah Mohd, Chin, Yit Siew, Arumugam, Manohar
Format: Article
Language:English
Subjects:
acid-base homeostasis
Acidosis
Acids
Blood pressure
Body fat
Body mass index
Cardiovascular disease
Cholesterol
Deoxyribonucleic acid
Diabetes
Diabetes mellitus
Diabetic retinopathy
Diet
DNA
Food
Gene polymorphism
Genes
Genetic analysis
Genotyping
Glucose
Health risks
Hypertension
Insulin
insulin growth factor-1
Insulin-like growth factor I
Interleukin 6
Lipids
Metabolism
Nucleotides
Nutrition research
Obesity
Polymorphism
Post-menopause
Potassium
Questionnaires
Regression analysis
Risk analysis
Risk factors
Single-nucleotide polymorphism
Sociodemographics
Vitamin D
Womens health
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Summary:The objective of this study was to explore the effects of dietary acid load (DAL) and IGF1 and IL6 gene polymorphisms and their potential diet–gene interactions on metabolic traits. A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid load (PRAL). Blood was drawn for biochemical parameters and DNA was extracted and Agena® MassARRAY was used for genotyping analysis to identify the signalling of IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) polymorphisms. Interactions between diet and genetic polymorphisms were assessed using regression analysis. The result showed that DAL was positively associated with fasting blood glucose (FBG) (β = 0.147, p < 0.05) and there was significant interaction effect between DAL and IL6 with systolic blood pressure (SBP) (β = 0.19, p = 0.041). In conclusion, these findings did not support the interaction effects between DAL and IGF1 and IL6 single nucleotide polymorphisms (rs35767, rs7136446, and rs1800796) on metabolic traits, except for SBP. Besides, higher DAL was associated with higher FBG, allowing us to postulate that high DAL is a potential risk factor for diabetes.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13072161