4-(Benzo[d]thiazol-2-yl)-1-(2-nitrophenyl)-1H-1,2,3-triazol-5-amine

The protocol for the reaction of 2-nitrophenyl azide with 2-(benzo[d]thiazol-2-yl)acetonitrile has been selected. It was found that an optimal condition under which the target 4-(benzo[d]thiazol-2-yl)-1-(2-nitrophenyl)-1H-1,2,3-triazol-5-amine could be formed in good yield is the triethylamine syste...

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Bibliographic Details
Published in:MolBank 2022-09, Vol.2022 (3), p.M1398
Main Authors: Pokhodylo, Nazariy T., Obushak, Mykola D.
Format: Article
Language:English
Subjects:
1,2,3-triazoles
2-(benzo[d]thiazol-2-yl)acetonitrile
Acetonitrile
aryl azides
Azide
Carbon
Catalysis
Chemical reactions
Conflicts of interest
Dimroth cyclization
Experiments
Optimization
organocatalysis
Reagents
Solvents
Triethylamine
Citations: Items that this one cites
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Summary:The protocol for the reaction of 2-nitrophenyl azide with 2-(benzo[d]thiazol-2-yl)acetonitrile has been selected. It was found that an optimal condition under which the target 4-(benzo[d]thiazol-2-yl)-1-(2-nitrophenyl)-1H-1,2,3-triazol-5-amine could be formed in good yield is the triethylamine system as a base in the DMF solution. The synthesized triazole is promising both for the evaluation of its antiproliferative properties and for the study of the path to new ring annulation by transforming nitro and amino groups.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1398