Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?

Background. Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation. Herein we present a case of 56-year-old male patient with no known history of recu...

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Bibliographic Details
Published in:Case reports in endocrinology 2018-01, Vol.2018 (2018), p.1-3
Main Authors: Hardjo Lugito, Nata Pratama, Kosasih, Felicia Nathania, Huang, Ian, Yanto, Theo Audi
Format: Article
Language:English
Subjects:
Antidiabetics
Case Report
Case reports
Causality
Clinical medicine
Diabetes
Dreams
Drug dosages
Health aspects
Hypoglycemia
Internal medicine
Medical research
Medicine
Medicine, Experimental
Metabolism
Metformin
Nightmares
Patients
Quality
Sleep
Sleep disorders
Systematic review
Type 2 diabetes
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Summary:Background. Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. Case Presentation. Herein we present a case of 56-year-old male patient with no known history of recurrent nightmares and sleep disorder, experiencing nightmare and abnormal dreams directly after consumption of 750 mg extended release metformin. He reported his dream as an unpleasant experience which awakened him at night with negative feelings. The nightmare only lasted for a night, but his dreams every night thereafter seemed abnormal. The dreams were vivid and indescribable. The disappearance and occurrence of abnormal dreams ensued soon after the drug was discontinued and rechallenged. The case was assessed using Naranjo Adverse Drug Reaction (ADR) probability scale and resulted as probable causality. Conclusion. Metformin might be the underlying cause of nightmare and abnormal dreams in this patient. More studies are needed to confirm the association and causality of this findings.
ISSN:2090-6501
2090-651X
DOI:10.1155/2018/7809305