Luteolin: a flavonoid with a multifaceted anticancer potential

Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, a...

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Published in:Cancer cell international 2022-12, Vol.22 (1), p.386-11, Article 386
Main Authors: Prasher, Parteek, Sharma, Mousmee, Singh, Sachin Kumar, Gulati, Monica, Chellappan, Dinesh Kumar, Zacconi, Flavia, De Rubis, Gabriele, Gupta, Gaurav, Sharifi-Rad, Javad, Cho, William C, Dua, Kamal
Format: Article
Language:English
Subjects:
Angiogenesis
Antitumor activity
Antitumor agents
Apoptosis
Cell cycle
Cell proliferation
Chemotherapy
Flavonoids
Inflammatory diseases
Kinases
Mortality
Oxidants
Oxidative stress
Phytochemicals
Polyphenols
Review
Tumorigenesis
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Summary:Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-022-02808-3