Loading…
Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics
To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography. The study included 126 eyes of healthy controls (n=32) and diabeti...
Saved in:
| Published in: | Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2018-01, Vol.12, p.419-425 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c576t-cb826645938de7b0199ca893b2141a790b365c0fc73c7b4d4e6af822023741d33 |
|---|---|
| cites | |
| container_end_page | 425 |
| container_issue | |
| container_start_page | 419 |
| container_title | Clinical ophthalmology (Auckland, N.Z.) |
| container_volume | 12 |
| creator | Fahmy, Rania M Bhat, Ramesa S Al-Mutairi, Manar Aljaser, Feda S El-Ansary, Afaf |
| description | To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography.
The study included 126 eyes of healthy controls (n=32) and diabetics patients (n=31), whose ages ranged from 40 to 70 years. The diabetic group was divided into: Subgroup 1: with HbA1c |
| doi_str_mv | 10.2147/OPTH.S151564 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7101485c3bd747b08ba6a71cb2b70de7</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A575198233</galeid><doaj_id>oai_doaj_org_article_7101485c3bd747b08ba6a71cb2b70de7</doaj_id><sourcerecordid>A575198233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c576t-cb826645938de7b0199ca893b2141a790b365c0fc73c7b4d4e6af822023741d33</originalsourceid><addsrcrecordid>eNptkl2LEzEYhQdR3HX1zmsJCOKFrfmaycyNsBR1Cwsr7Hodksw7bWqajMnMSv-9GVtLKxJIQvLkvMnJKYrXBM8p4eLj3beHm_k9KUlZ8SfFJSFCzEpes6fHeSUuihcpbTCuKK7F8-KCNiUredNcFuMixAhODTZ4pGH4BeDRyu0MbK1BJvghBoeUb1EP0faqt86puEMRBuuVQx7iI6DOaojIqV3uh7U1PzykhKxH92psLRp2PaDlErVW5RLWpJfFs065BK8O41Xx_cvnh8XN7Pbu63JxfTszpaiGmdE1rSpeNqxuQWhMmsaoumE6P5wo0WDNqtLgzghmhOYth0p1NaWYMsFJy9hVsdzrtkFtZB_tNt9dBmXln4UQV1LFfCEHUhBMeF0aplvBc61aq0oJYjTVAufqWevTXqsf9RZaA9ka5c5Ez3e8XctVeJRlzTGpqyzw_iAQw88R0iC3NhnIfnoIY5IUEyYyxyb07T_oJowx-50pSvPHccZPqJXKD7C-C7mumUTldSlK0tSUTR7M_0Pl1k5fHDx0Nq-fHXh3cmANyg3rFNw4RSSdgx_2oIkhpQjd0QyC5ZRNOWVTHrKZ8TenBh7hv2FkvwFnTd37</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2224994346</pqid></control><display><type>article</type><title>Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics</title><source>Taylor & Francis (Open Access)</source><source>PMC (PubMed Central)</source><source>Publicly Available Content (ProQuest)</source><creator>Fahmy, Rania M ; Bhat, Ramesa S ; Al-Mutairi, Manar ; Aljaser, Feda S ; El-Ansary, Afaf</creator><creatorcontrib>Fahmy, Rania M ; Bhat, Ramesa S ; Al-Mutairi, Manar ; Aljaser, Feda S ; El-Ansary, Afaf</creatorcontrib><description>To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography.
The study included 126 eyes of healthy controls (n=32) and diabetics patients (n=31), whose ages ranged from 40 to 70 years. The diabetic group was divided into: Subgroup 1: with HbA1c <7% and Subgroup 2: with HbA1c ≥7%. All patients underwent full ophthalmic examination. HbA1c level was obtained with the A1cNow
system and the peripapillary RNFLT was measured using 3D-OCT 2000 Topcon (360-degree circular scan with 3.4 mm diameter centered on optic disc).
The obtained data demonstrates significant decrease in peripapillary RNFLT in superior and inferior quadrants of the right eye (
=0.000 and
=0.039, respectively), and in superior quadrant of the left eye (
=0.002) with impairment of glycemic control. Pearson's correlation test showed significant negative correlation of RNFLT with HbA1c in the superior quadrant in both eyes.
Impairment of glycemic control affects the peripapillary RNFLT mainly in the superior quadrant. This thickness also tends to decrease with long-standing DM, use of DM medications, and development of diabetic retinopathy. The measurement of peripapillary RNFLT may become a useful method to monitor early retinal changes in diabetic patients.</description><identifier>ISSN: 1177-5467</identifier><identifier>ISSN: 1177-5483</identifier><identifier>EISSN: 1177-5483</identifier><identifier>DOI: 10.2147/OPTH.S151564</identifier><identifier>PMID: 29535499</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Chronic illnesses ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes therapy ; Diabetic neuropathy ; Diabetic retinopathy ; Diabetics ; Edema ; Glucose ; Glycosylated hemoglobin ; Gram-positive bacteria ; Hemoglobins ; Hospitals ; Insulin resistance ; Laboratories ; Mortality ; Ophthalmology ; optical coherence tomography ; Optics ; Original Research ; Probiotics ; Retina ; RNFL ; Statistical analysis ; Tomography ; Type 2 diabetes</subject><ispartof>Clinical ophthalmology (Auckland, N.Z.), 2018-01, Vol.12, p.419-425</ispartof><rights>COPYRIGHT 2018 Dove Medical Press Limited</rights><rights>2018. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Fahmy et al. This work is published and licensed by Dove Medical Press Limited 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-cb826645938de7b0199ca893b2141a790b365c0fc73c7b4d4e6af822023741d33</citedby><orcidid>0000-0002-1404-5248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2224994346/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2224994346?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29535499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fahmy, Rania M</creatorcontrib><creatorcontrib>Bhat, Ramesa S</creatorcontrib><creatorcontrib>Al-Mutairi, Manar</creatorcontrib><creatorcontrib>Aljaser, Feda S</creatorcontrib><creatorcontrib>El-Ansary, Afaf</creatorcontrib><title>Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics</title><title>Clinical ophthalmology (Auckland, N.Z.)</title><addtitle>Clin Ophthalmol</addtitle><description>To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography.
The study included 126 eyes of healthy controls (n=32) and diabetics patients (n=31), whose ages ranged from 40 to 70 years. The diabetic group was divided into: Subgroup 1: with HbA1c <7% and Subgroup 2: with HbA1c ≥7%. All patients underwent full ophthalmic examination. HbA1c level was obtained with the A1cNow
system and the peripapillary RNFLT was measured using 3D-OCT 2000 Topcon (360-degree circular scan with 3.4 mm diameter centered on optic disc).
The obtained data demonstrates significant decrease in peripapillary RNFLT in superior and inferior quadrants of the right eye (
=0.000 and
=0.039, respectively), and in superior quadrant of the left eye (
=0.002) with impairment of glycemic control. Pearson's correlation test showed significant negative correlation of RNFLT with HbA1c in the superior quadrant in both eyes.
Impairment of glycemic control affects the peripapillary RNFLT mainly in the superior quadrant. This thickness also tends to decrease with long-standing DM, use of DM medications, and development of diabetic retinopathy. The measurement of peripapillary RNFLT may become a useful method to monitor early retinal changes in diabetic patients.</description><subject>Chronic illnesses</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes therapy</subject><subject>Diabetic neuropathy</subject><subject>Diabetic retinopathy</subject><subject>Diabetics</subject><subject>Edema</subject><subject>Glucose</subject><subject>Glycosylated hemoglobin</subject><subject>Gram-positive bacteria</subject><subject>Hemoglobins</subject><subject>Hospitals</subject><subject>Insulin resistance</subject><subject>Laboratories</subject><subject>Mortality</subject><subject>Ophthalmology</subject><subject>optical coherence tomography</subject><subject>Optics</subject><subject>Original Research</subject><subject>Probiotics</subject><subject>Retina</subject><subject>RNFL</subject><subject>Statistical analysis</subject><subject>Tomography</subject><subject>Type 2 diabetes</subject><issn>1177-5467</issn><issn>1177-5483</issn><issn>1177-5483</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl2LEzEYhQdR3HX1zmsJCOKFrfmaycyNsBR1Cwsr7Hodksw7bWqajMnMSv-9GVtLKxJIQvLkvMnJKYrXBM8p4eLj3beHm_k9KUlZ8SfFJSFCzEpes6fHeSUuihcpbTCuKK7F8-KCNiUredNcFuMixAhODTZ4pGH4BeDRyu0MbK1BJvghBoeUb1EP0faqt86puEMRBuuVQx7iI6DOaojIqV3uh7U1PzykhKxH92psLRp2PaDlErVW5RLWpJfFs065BK8O41Xx_cvnh8XN7Pbu63JxfTszpaiGmdE1rSpeNqxuQWhMmsaoumE6P5wo0WDNqtLgzghmhOYth0p1NaWYMsFJy9hVsdzrtkFtZB_tNt9dBmXln4UQV1LFfCEHUhBMeF0aplvBc61aq0oJYjTVAufqWevTXqsf9RZaA9ka5c5Ez3e8XctVeJRlzTGpqyzw_iAQw88R0iC3NhnIfnoIY5IUEyYyxyb07T_oJowx-50pSvPHccZPqJXKD7C-C7mumUTldSlK0tSUTR7M_0Pl1k5fHDx0Nq-fHXh3cmANyg3rFNw4RSSdgx_2oIkhpQjd0QyC5ZRNOWVTHrKZ8TenBh7hv2FkvwFnTd37</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Fahmy, Rania M</creator><creator>Bhat, Ramesa S</creator><creator>Al-Mutairi, Manar</creator><creator>Aljaser, Feda S</creator><creator>El-Ansary, Afaf</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1404-5248</orcidid></search><sort><creationdate>20180101</creationdate><title>Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics</title><author>Fahmy, Rania M ; Bhat, Ramesa S ; Al-Mutairi, Manar ; Aljaser, Feda S ; El-Ansary, Afaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c576t-cb826645938de7b0199ca893b2141a790b365c0fc73c7b4d4e6af822023741d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chronic illnesses</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes therapy</topic><topic>Diabetic neuropathy</topic><topic>Diabetic retinopathy</topic><topic>Diabetics</topic><topic>Edema</topic><topic>Glucose</topic><topic>Glycosylated hemoglobin</topic><topic>Gram-positive bacteria</topic><topic>Hemoglobins</topic><topic>Hospitals</topic><topic>Insulin resistance</topic><topic>Laboratories</topic><topic>Mortality</topic><topic>Ophthalmology</topic><topic>optical coherence tomography</topic><topic>Optics</topic><topic>Original Research</topic><topic>Probiotics</topic><topic>Retina</topic><topic>RNFL</topic><topic>Statistical analysis</topic><topic>Tomography</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fahmy, Rania M</creatorcontrib><creatorcontrib>Bhat, Ramesa S</creatorcontrib><creatorcontrib>Al-Mutairi, Manar</creatorcontrib><creatorcontrib>Aljaser, Feda S</creatorcontrib><creatorcontrib>El-Ansary, Afaf</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinical ophthalmology (Auckland, N.Z.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fahmy, Rania M</au><au>Bhat, Ramesa S</au><au>Al-Mutairi, Manar</au><au>Aljaser, Feda S</au><au>El-Ansary, Afaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics</atitle><jtitle>Clinical ophthalmology (Auckland, N.Z.)</jtitle><addtitle>Clin Ophthalmol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>12</volume><spage>419</spage><epage>425</epage><pages>419-425</pages><issn>1177-5467</issn><issn>1177-5483</issn><eissn>1177-5483</eissn><abstract>To evaluate the effect of diabetes mellitus (DM), diabetic retinopathy, and degree of glycemic control (glycosylated hemoglobin [HbA1c]) on peripapillary retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography.
The study included 126 eyes of healthy controls (n=32) and diabetics patients (n=31), whose ages ranged from 40 to 70 years. The diabetic group was divided into: Subgroup 1: with HbA1c <7% and Subgroup 2: with HbA1c ≥7%. All patients underwent full ophthalmic examination. HbA1c level was obtained with the A1cNow
system and the peripapillary RNFLT was measured using 3D-OCT 2000 Topcon (360-degree circular scan with 3.4 mm diameter centered on optic disc).
The obtained data demonstrates significant decrease in peripapillary RNFLT in superior and inferior quadrants of the right eye (
=0.000 and
=0.039, respectively), and in superior quadrant of the left eye (
=0.002) with impairment of glycemic control. Pearson's correlation test showed significant negative correlation of RNFLT with HbA1c in the superior quadrant in both eyes.
Impairment of glycemic control affects the peripapillary RNFLT mainly in the superior quadrant. This thickness also tends to decrease with long-standing DM, use of DM medications, and development of diabetic retinopathy. The measurement of peripapillary RNFLT may become a useful method to monitor early retinal changes in diabetic patients.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>29535499</pmid><doi>10.2147/OPTH.S151564</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1404-5248</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1177-5467 |
| ispartof | Clinical ophthalmology (Auckland, N.Z.), 2018-01, Vol.12, p.419-425 |
| issn | 1177-5467 1177-5483 1177-5483 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_7101485c3bd747b08ba6a71cb2b70de7 |
| source | Taylor & Francis (Open Access); PMC (PubMed Central); Publicly Available Content (ProQuest) |
| subjects | Chronic illnesses Development and progression Diabetes Diabetes mellitus Diabetes therapy Diabetic neuropathy Diabetic retinopathy Diabetics Edema Glucose Glycosylated hemoglobin Gram-positive bacteria Hemoglobins Hospitals Insulin resistance Laboratories Mortality Ophthalmology optical coherence tomography Optics Original Research Probiotics Retina RNFL Statistical analysis Tomography Type 2 diabetes |
| title | Correlation between glycemic control and peripapillary retinal nerve fiber layer thickness in Saudi type II diabetics |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T18%3A14%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20glycemic%20control%20and%20peripapillary%20retinal%20nerve%20fiber%20layer%20thickness%20in%20Saudi%20type%20II%20diabetics&rft.jtitle=Clinical%20ophthalmology%20(Auckland,%20N.Z.)&rft.au=Fahmy,%20Rania%20M&rft.date=2018-01-01&rft.volume=12&rft.spage=419&rft.epage=425&rft.pages=419-425&rft.issn=1177-5467&rft.eissn=1177-5483&rft_id=info:doi/10.2147/OPTH.S151564&rft_dat=%3Cgale_doaj_%3EA575198233%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c576t-cb826645938de7b0199ca893b2141a790b365c0fc73c7b4d4e6af822023741d33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2224994346&rft_id=info:pmid/29535499&rft_galeid=A575198233&rfr_iscdi=true |