Dermatophyte infection: from fungal pathogenicity to host immune responses

Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of gre...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2023, Vol.14, p.1285887-1285887
Main Authors: Deng, Ruixin, Wang, Xiaowen, Li, Ruoyu
Format: Article
Language:English
Subjects:
Arthrodermataceae
caspase-associated recruitment domain 9
Dermatomycoses
dermatophyte
Humans
Immunity
innate immune response
pattern recognition receptors
protease
Tinea - microbiology
type 1 immune response
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of great help to understand the pathogenesis of dermatophytes, including fungal virulence factors and anti-pathogen immune responses. This review aims to summarize the recent advances in host-fungal interactions, focusing on the mechanisms of anti-fungal immunity and the relationship between immune deficiency and chronic dermatophytosis, in order to facilitate novel diagnostic and therapeutic approaches to improve the outcomes of these patients.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1285887