Costs Analysis of Fibrin Sealant for Prevention of Anastomotic Leakage in Lower Colorectal Surgery

Postoperative anastomotic leaks remain a common and serious complication of colorectal surgeries and are a major cause of mortality and morbidity of these procedures. Anastomotic leaks (AL) have been extensively studied; however, there has been no significant reduction in their prevalence over time....

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Bibliographic Details
Published in:Risk management and healthcare policy 2020-01, Vol.13, p.5-11
Main Authors: Panda, Saswat, Connolly, Mark P, Ramirez, Manuel G, Beltrán de Heredia, Juan
Format: Article
Language:English
Subjects:
anastomoses
budget impact
Colorectal cancer
Colorectal surgery
Confidence intervals
Cost analysis
fibrin sealant
Intervention
Literature reviews
Mortality
Original Research
Sealants
Sealing compounds
Studies
Surgical outcomes
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Summary:Postoperative anastomotic leaks remain a common and serious complication of colorectal surgeries and are a major cause of mortality and morbidity of these procedures. Anastomotic leaks (AL) have been extensively studied; however, there has been no significant reduction in their prevalence over time. In addition, there is a significant economic burden from AL attributed to the need for repeat surgery, radiologic intervention and lengthened hospital stay. We conducted a comparative cost analysis of patients undergoing colorectal surgery with anastomosis, with the application of fibrin sealant (FS) to the sutured anastomosis versus not treating the sutured anastomosis with FS. The deterministic decision-tree model was populated with clinical data including operating room time, hospitalization days, occurrence of AL, need for revision surgery, blood products and radiologic interventions to treat the AL in lower colorectal surgery. A systematic literature review was conducted to identify appropriate studies with these variables. The average cost per case treated lower colorectal surgery with fibrin sealant glue 10 mL Tisseel and those not treated with a fibrin sealant after suturing the anastomoses was €3233 and €4130, respectively, for resource expenses paid by the healthcare system. This would suggest potential savings of €897 per surgery, achieved through the application of FS to the sutured anastomosis for preventing AL following colorectal surgery. Application of FS to the sutured anastomosis in lower colorectal surgery resulted in a decrease in post-operative AL, and cost savings based on a reduction in hospitalization days, a reduction needing: revision surgery, radiologic intervention and blood products to treat AL.
ISSN:1179-1594
1179-1594
DOI:10.2147/RMHP.S221008