Current Insights into Oral Cancer Epigenetics

Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression pat...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-02, Vol.19 (3), p.670
Main Authors: Irimie, Alexandra Iulia, Ciocan, Cristina, Gulei, Diana, Mehterov, Nikolay, Atanasov, Atanas G, Dudea, Diana, Berindan-Neagoe, Ioana
Format: Article
Language:English
Subjects:
DNA methylation
Epigenetics
Gene expression
histone
Malignancy
miRNA
non-coding RNAs
Oral cancer
Review
Risk analysis
Risk factors
Therapeutic applications
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Summary:Epigenetic modifications have emerged into one of the cancer hallmarks, replacing the concept of malignant pathologies as being solely genetic-based conditions. The epigenetic landscape is responsible for normal development but also for the heterogeneity among tissues in terms of gene expression patterns. Dysregulation in these mechanisms has been associated with disease stage, and increased attention is now granted to cancer in order to take advantage of these modifications in terms of novel therapeutic strategies or diagnosis/prognosis tools. Oral cancer has also been subjected to epigenetic analysis with numerous studies revealing that the development and progression of this malignancy are partially induced by an altered epigenetic substrate together with genetic alterations and prolonged exposure to environmental risk factors. The present review summarizes the most important epigenetic modifications associated with oral cancer and also their potential to be used as new therapeutic targets.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19030670