Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient

Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fl...

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Bibliographic Details
Published in:Annals of Saudi medicine 2010-09, Vol.30 (5), p.404-407
Main Authors: Al-Qadheeb, Nada S, Althawadi, Sahar, Alkhalaf, Abdulaziz, Hosaini, Suleiman, Alrajhi, Abdulrahman A
Format: Article
Language:English
Subjects:
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Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacteria
Bacterial pneumonia
Bacterial Proteins - biosynthesis
beta-Lactamases - biosynthesis
Blood
Case Report
Case studies
Community-Acquired Infections - drug therapy
Diagnosis
Disease
Drug resistance in microorganisms
Drug Resistance, Multiple, Bacterial
Drug therapy
Fatal Outcome
Gram-Negative Bacterial Infections - drug therapy
Gram-Negative Bacterial Infections - microbiology
Health aspects
Health facilities
Heart failure
Humans
Klebsiella
Klebsiella Infections - drug therapy
Klebsiella Infections - enzymology
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - enzymology
Male
Minocycline - analogs & derivatives
Minocycline - pharmacology
Minocycline - therapeutic use
Organisms
Patient outcomes
Pneumonia
Risk factors
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Summary:Carbapenemase-producing Klebsiella pneumoniae infections carry serious clinical and infection-control implications. Isolates possessing such hydrolyzing enzymes have been described in the United States and around the world. Besides being resistant to carbapenems, they usually confer resistance to fluoroquinolones, piperacillin-tazobactam, and extended-spectrum cephalosporins. Tigecycline demonstrates in vitro activity against these organisms, but reported resistance raises concern about tigecycline use for these infections. We describe a carbapenemase-producing K pneumoniae evolving resistance to tigecycline in a 75-year-old male after a prolonged stay in a critical care unit.
ISSN:0256-4947
0975-4466
DOI:10.4103/0256-4947.67087