Antimicrobial resistance in bacterial pathogens among hospitalized children with community acquired lower respiratory tract infections in Dongguan, China (2011-2016)

• Published in: BMC infectious diseases 2017-09, Vol.17 (1), p.614-614, Article 614
• Main Authors: He, Xiaoguang, Xie, Mingyu, Li, Siping, Ye, Junqin, Peng, Qi, Ma, Qiang, Lu, Xiaomei, Zhong, Baimao
• Format: Article
• Language: English
• Subjects: Abuse; Analysis; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Antimicrobial resistance; Bacteria; Bacterial Infections - drug therapy; Bacterial Infections - epidemiology; Bacterial Infections - microbiology; Carbapenems; Cephalosporins; Child, Hospitalized - statistics & numerical data; Child, Preschool; Children; China - epidemiology; Chlamydia; Chlamydia pneumoniae; Clinical medicine; Communities; Community-Acquired Infections - drug therapy; Community-Acquired Infections - epidemiology; Community-Acquired Infections - microbiology; Diffusion tests; Drug resistance; Drug Resistance, Bacterial - drug effects; E coli; Epidemiology; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - isolation & purification; Female; Fluoroquinolones; Health risks; Hospitals; Humans; Infant; Infant, Newborn; Infants; Infections; Infectious diseases; Intensive care; Klebsiella pneumoniae; Laboratories; Male; Microbial Sensitivity Tests; Mycoplasma pneumoniae; Pathogens; Pediatrics; Pneumonia; Pseudomonas aeruginosa; Respiratory tract; Respiratory tract diseases; Respiratory tract infection; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - microbiology; Retrospective Studies; Sputum; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - isolation & purification; Streptococcus; Streptococcus infections; Streptococcus pneumoniae; Vancomycin
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-017-2710-4

Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bacterial agents among hospitalized children with CA-LRTIs between 2011 and 2016 in Dongguan, China. Sputum samples were collected from hospitalized children (0-5 years old) with CA-LRTIs in Dongguan Children's Hospital. Bacterial pathogens were detected using traditional culture methods, and disc diffusion tests were used to determine antibiotic resistance. Among the 2360 samples analyzed, 342 (14.5%) were positive for bacterial infection. The most prevalent pathogen was MSSA (2.3%), followed by MRSA (1.5%), E. coli (1.7%), E. coli ESBLs (1.2%), K. pneumonia ESBLs (1.5%), K. pneumonia (1.4%) and S. pneumonia (1.3%). Of the hospitalized patients with bacteria causing of CA-LRTIs, 90.1% were less than 1-year-old. MSSA and MRSA were more commonly isolated in infants less than 3 months. E. coli, K. pneumonia and K. pneumonia ESBLs were more common bacteria causing CA-LRTIs in infants less than 1 month. Resistance levels to penicillins, fluoroquinolones, macrolides, cephalosporins, carbapenems and vancomycin varied in different bacteria. S. aureus, E coli and K. pneumonia were the common bacterial isolates recovered from chidren with CA-LTRIs during 2011-2015. Age group of under 1 year old was at a high risk of bacterial infections. Many isolates showed antibiotic resistance level was associated with antibiotic usage in clinic. Increasing surveillance of antibiotic resistance is urgently needed and develops better strategies to cure the antibiotic abuse in China.