Intraoperative Photodynamic Diagnosis Using Talaporfin Sodium Simultaneously Applied for Photodynamic Therapy against Malignant Glioma: A Prospective Clinical Study

The goal of this study was to demonstrate the feasibility of intraoperative photodynamic diagnosis (PDD) of malignant glioma using the fluorescence from talaporfin sodium (TS), which is used simultaneously for photodynamic therapy (PDT). Patients with suspected primary malignant glioma who were elig...

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Bibliographic Details
Published in:Frontiers in neurology 2018-01, Vol.9, p.24-24
Main Authors: Shimizu, Kazuhide, Nitta, Masayuki, Komori, Takashi, Maruyama, Takashi, Yasuda, Takayuki, Fujii, Yu, Masamune, Ken, Kawamata, Takakazu, Maehara, Taketoshi, Muragaki, Yoshihiro
Format: Article
Language:English
Subjects:
glioblastoma
malignant glioma
Neuroscience
NPe6
photodynamic diagnosis
photodynamic therapy
talaporfin sodium
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Summary:The goal of this study was to demonstrate the feasibility of intraoperative photodynamic diagnosis (PDD) of malignant glioma using the fluorescence from talaporfin sodium (TS), which is used simultaneously for photodynamic therapy (PDT). Patients with suspected primary malignant glioma who were eligible for surgical removal of the tumor and PDT with TS were enrolled in this prospective study. Tissue samples were obtained from the contrast-enhanced (CE) region and from the surrounding non-contrast-enhanced (NCE) marginal tissue at the boundary between the tumor and normal tissue. The excised samples were set into a fluorescence measurement system, which consisted of a semiconductor laser with a 400-nm wavelength for excitation, and a compact spectrometer for detection, which were applied and received through a custom-made probe consisting of coaxial optical fibers. The fluorescence spectrum was obtained, and peak intensity was calculated. Tumor cellularity was histopathologically analyzed and semi-quantitatively classified into four (0-3) categories. 86 samples from 17 surgical cases were available for fluorescence measurement and analysis. The fluorescence from TS had a single peak at 664 nm that was easily distinguished from the 400-nm excitation light. Samples from the CE regions showed higher fluorescence intensity than those from the NCE regions (  
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2018.00024