Endogenous growth hormone and insulin after interposition of a reversed jejunal segment in short bowel syndrome. An experimental study on pigs

Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiolog...

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Bibliographic Details
Published in:BMC research notes 2012-08, Vol.5 (1), p.463-463, Article 463
Main Authors: Papamichail, Michail, Digalakis, Michail, Panagiotis, Prigouris, Paisios, Odysseas, Loti, Soyltana, Sergentanis, Theodoros
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Body Weight
Disease Models, Animal
Endocrine disruptors
Gastrointestinal Motility
Growth hormone
Growth Hormone - blood
Growth hormones
Humans
Independent sample
Insulin
Insulin - blood
Jejunum - metabolism
Jejunum - surgery
Malabsorption syndromes
Medical research
Medicine, Experimental
Reversed jejunal segment
Serum Albumin - analysis
Short bowel syndrome
Short Bowel Syndrome - blood
Short Bowel Syndrome - surgery
Short Report
Somatotropin
Studies
Swine
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Summary:Interposition of a reversed jejunal loop in short bowel sydrome has previously been investigated in human along with animal models and seemed able to facilitate intestinal adaptation. However, it is unclear if growth hormone and insulin, well known for their implication in short bowel pathophysiology, intervene on this effect. Porcine models were randomly allocated to two cohorts: (1) short bowel (SB) group (n = 8) and (2) short bowel reverse jejunal segment (SB-RS) group (n = 8). Amongst other parameters serum growth hormone and insulin were measured at baseline, as well as on postoperative day 30 and 60. Both endogenous hormones failed to demonstrate significant difference in respect to potential direct effect to mechanisms of enhanced intestinal adaptation in reversed group.
ISSN:1756-0500
1756-0500
DOI:10.1186/1756-0500-5-463