Focal Segmental Glomerulosclerosis in Waldenström’s Macroglobulinemia

Renal involvement in Waldenström’s macroglobulinemia is a rare manifestation. Although most renal involvement is due to monoclonal immune deposits, pathology can also be unrelated to it. Here, we describe a 68-year-old female with a history of Waldenström’s macroglobulinemia who presented with gener...

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Bibliographic Details
Published in:Case reports in nephrology 2020-08, Vol.2020 (2020), p.1-3
Main Authors: Batra, Akshee, Thajudeen, Bijin, Herz Allah, Shatha
Format: Article
Language:English
Subjects:
Biopsy
Blood
Case Report
Case reports
Chemotherapy
Creatinine
Edema
Hematology
Kidney diseases
Light
Lymphoma
Microscopy
Nephrology
Pathogenesis
Pathology
Patients
Proteins
Stem cells
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Summary:Renal involvement in Waldenström’s macroglobulinemia is a rare manifestation. Although most renal involvement is due to monoclonal immune deposits, pathology can also be unrelated to it. Here, we describe a 68-year-old female with a history of Waldenström’s macroglobulinemia who presented with generalized edema and nephrotic range proteinuria. A renal biopsy showed findings consistent with focal segmental glomerulosclerosis. Treatment with oral prednisone leads to the resolution of proteinuria. This case highlights the importance of identifying pathology that might not be directly related to monoclonal gammopathy, which could have implications on the management.
ISSN:2090-6641
2090-665X
DOI:10.1155/2020/8895705