Matrix Metalloproteinases as Regulators of Periodontal Inflammation

Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence de...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-02, Vol.18 (2), p.440-440
Main Authors: Franco, Cavalla, Patricia, Hernández-Ríos, Timo, Sorsa, Claudia, Biguetti, Marcela, Hernández
Format: Article
Language:English
Subjects:
chronic periodontitis
Enzyme Activation
Humans
Infectious diseases
Inflammation
Inflammation - enzymology
Matrix Metalloproteinases - metabolism
Medicin och hälsovetenskap
MMPs
Models, Biological
modulation
Periodontal Diseases - enzymology
periodontal inflammation regulation
Periodontics
Review
Signal Transduction
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Summary:Periodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the 'protease web' is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules-such as cytokines, chemokines, and growth factors, among others-regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18020440