Current status and etiology of valvular heart disease in China: a population-based survey

• Published in: BMC cardiovascular disorders 2021-07, Vol.21 (1), p.339-339, Article 339
• Main Authors: Yang, Ying, Wang, Zengwu, Chen, Zuo, Wang, Xin, Zhang, Linfeng, Li, Suning, Zheng, Congyi, Kang, Yuting, Jiang, Linlin, Zhu, Zhenhui, Gao, Runlin
• Format: Article
• Language: English
• Subjects: Adult; Age; Age Factors; Aged; Cardiomyopathy; Cardiovascular disease; Causes of; China; Cholesterol; Congenital diseases; Coronary artery disease; Creatinine; Cross-Sectional Studies; Degenerative; Developing countries; Diabetes; Diagnosis; Distribution; Echocardiography; Echocardiography, Doppler; Epidemiology; Etiology; Female; Health Surveys; Heart diseases; Heart failure; Heart valve diseases; Heart Valve Diseases - diagnostic imaging; Heart Valve Diseases - epidemiology; Humans; Hypertension; Hypertension - epidemiology; Ischemia; Kidney diseases; LDCs; Male; Middle Aged; Population; Prevalence; Prospective Studies; Questionnaires; Rheumatic; Rheumatic heart disease; Rheumatic Heart Disease - diagnostic imaging; Rheumatic Heart Disease - epidemiology; Risk Assessment; Risk Factors; Statistical sampling; Valvular heart disease
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-021-02154-8

The epidemiology of valvular heart disease (VHD) has changed markedly over the last 50 years worldwide, and the prevalence and features of VHD in China are unknown. The objective of this study was to investigate the current status and etiology of VHD in China. We used a cross-sectional national survey with stratified multistage random sampling from the general Chinese population to estimate the VHD burden. Data on demographic characteristics, medical history, physical examination, blood tests, and potential etiology were collected. Echocardiography was used to detect VHD. The national survey enrolled 34,994 people aged 35 years or older across China. Overall, 31,499 people were included in the final analysis, and 1309 participants were diagnosed with VHD. The weighted prevalence was 3.8%, with an estimated 25 million patients in China. The prevalence of VHD increased with age and was higher in participants with hypertension or chronic kidney disease than in their counterparts. Among participants with VHD, 55.1% were rheumatic and 21.3% were degenerative. The proportion of rheumatic decreased with age, and the proportion of degenerative rose with age. However, the prevalence of rheumatic disease was still higher in the elderly population than in the younger population. Logistic regression revealed that age and hypertension were correlated with VHD. In China, rheumatic heart disease was still the major cause of the VHD, with a significant increase in degenerative heart disease. Age and hypertension are important and easily identifiable markers of VHD.