Phytosterols: Potential Metabolic Modulators in Neurodegenerative Diseases

Phytosterols constitute a class of natural products that are an important component of diet and have vast applications in foods, cosmetics, and herbal medicines. With many and diverse isolated structures in nature, they exhibit a broad range of biological and pharmacological activities. Among over 2...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (22), p.12255
Main Authors: Sharma, Niti, Tan, Mario A, An, Seong Soo A
Format: Article
Language:English
Subjects:
Alzheimer's disease
Apolipoproteins
Biosynthesis
blood brain barrier
Brain - metabolism
Brain - pathology
Cholesterol
Cosmetics
Diet
FDA approval
Herbal medicine
High density lipoprotein
Humans
Kinases
Lipids
Metabolism
Molecular Structure
Multiple sclerosis
Natural products
Neurodegeneration
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - prevention & control
Neuromodulation
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacokinetics
Neuroprotective Agents - therapeutic use
Phytosterols
Phytosterols - chemistry
Phytosterols - pharmacokinetics
Phytosterols - therapeutic use
Phytotherapy - methods
Plants, Medicinal - chemistry
Proteins
Review
Reviews
Sitosterols - chemistry
Sitosterols - pharmacokinetics
Sitosterols - therapeutic use
Sterols
Stigmasterol - chemistry
Stigmasterol - pharmacokinetics
Stigmasterol - therapeutic use
Tumor necrosis factor-TNF
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Summary:Phytosterols constitute a class of natural products that are an important component of diet and have vast applications in foods, cosmetics, and herbal medicines. With many and diverse isolated structures in nature, they exhibit a broad range of biological and pharmacological activities. Among over 200 types of phytosterols, stigmasterol and β-sitosterol were ubiquitous in many plant species, exhibiting important aspects of activities related to neurodegenerative diseases. Hence, this mini-review presented an overview of the reported studies on selected phytosterols related to neurodegenerative diseases. It covered the major phytosterols based on biosynthetic considerations, including other phytosterols with significant in vitro and in vivo biological activities.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222212255