Comparative study of two types of herbal capsules with different Epimedium species for the prevention of ovariectomised-induced osteoporosis in rats

Epimedii Folium is the most important osteogenic herb formulated for the traditional Chinese Medicine Xian Ling Gu Bao (XLGB) capsule. The present study compared XLGB capsules containing two different Epimedium species, i.e., either Epimedium pubescens (XEP) or Epimedium koreanum (XEK), with the foc...

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Bibliographic Details
Published in:Journal of orthopaedic translation 2016-01, Vol.4 (C), p.14-27
Main Authors: Chen, Shi-Hui, Wang, Xin-Luan, Zheng, Li-Zhen, Dai, Yi, Zhang, Jia-Yong, Guo, Bao-Lin, Yang, Zhi-Jun, Yao, Xin-Sheng, Qin, Ling
Format: Article
Language:English
Subjects:
Epimedium
Original
osteoporosis
ovariectomised rats
treatment efficacy
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Summary:Epimedii Folium is the most important osteogenic herb formulated for the traditional Chinese Medicine Xian Ling Gu Bao (XLGB) capsule. The present study compared XLGB capsules containing two different Epimedium species, i.e., either Epimedium pubescens (XEP) or Epimedium koreanum (XEK), with the focus being on the chemical constituents and antiosteoporotic efficacy. Ultra performance liquid chromatography was used to demonstrate the different chemical constituents. Biomechanical tests, histological, and cytological evaluation were performed to characterise and compare the bone mineral density, bone strength, microstructure of bone tissue, and biological activity between XEP and XEK using an established ovariectomised (OVX) rat model. Six flavonoids with different contents between XEK and XEP were identified. As compared with the OVX group, significantly higher bone mineral density, elastic-modulus, and compressive strength were found in both the XEK group and XEP group (p 
ISSN:2214-031X
2214-0328
DOI:10.1016/j.jot.2015.07.001