Tegument Assembly and Secondary Envelopment of Alphaherpesviruses

Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their ability to establish lifelong latent infection in neurons. As for all herpesviruses, alphaherpesvirus virions contain a protein-rich layer called "tegument" that links the DNA-containing capsid to the...

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Bibliographic Details
Published in:Viruses 2015-09, Vol.7 (9), p.5084-5114
Main Authors: Owen, Danielle J, Crump, Colin M, Graham, Stephen C
Format: Article
Language:English
Subjects:
Alphaherpesvirinae - physiology
herpes simplex virus
HSV-1
Models, Biological
Protein Binding
PrV
pseudorabies virus
Review
Viral Structural Proteins - metabolism
Virus Assembly
virus egress
virus maturation
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Summary:Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their ability to establish lifelong latent infection in neurons. As for all herpesviruses, alphaherpesvirus virions contain a protein-rich layer called "tegument" that links the DNA-containing capsid to the glycoprotein-studded membrane envelope. Tegument proteins mediate a diverse range of functions during the virus lifecycle, including modulation of the host-cell environment immediately after entry, transport of virus capsids to the nucleus during infection, and wrapping of cytoplasmic capsids with membranes (secondary envelopment) during virion assembly. Eleven tegument proteins that are conserved across alphaherpesviruses have been implicated in the formation of the tegument layer or in secondary envelopment. Tegument is assembled via a dense network of interactions between tegument proteins, with the redundancy of these interactions making it challenging to determine the precise function of any specific tegument protein. However, recent studies have made great headway in defining the interactions between tegument proteins, conserved across alphaherpesviruses, which facilitate tegument assembly and secondary envelopment. We summarize these recent advances and review what remains to be learned about the molecular interactions required to assemble mature alphaherpesvirus virions following the release of capsids from infected cell nuclei.
ISSN:1999-4915
1999-4915
DOI:10.3390/v7092861