Clinical importance of fibulin-5 immunohistochemical staining in breast lesions

The aim of this study was to evaluate the clinical importance of fibulin-5, which has been shown to display tumour-promoting and tumour-protective functions in breast lesions. Sixty-two breast cancer patients, 19 patients with fibroadenoma, and 15 healthy breast tissues were enrolled. Forty-seven pa...

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Bibliographic Details
Published in:Polish journal of pathology 2019-01, Vol.70 (4), p.259-263
Main Authors: Karanis, Meryem, Koksal, Hande, Ates, Emet, Dogru, Osman
Format: Article
Language:English
Subjects:
Age
Angiogenesis
Breast
Breast cancer
Breast Neoplasms - diagnosis
Carcinoma, Ductal, Breast - diagnosis
Carcinoma, Lobular - diagnosis
Cell growth
Extracellular matrix
Extracellular Matrix Proteins - analysis
Female
fibroadenoma
Fibroadenoma - diagnosis
fibulin-5
Hormone replacement therapy
Humans
Immunohistochemistry
Kinases
Medical prognosis
Proteins
Staining and Labeling
Statistical analysis
Triple Negative Breast Neoplasms
Vascular endothelial growth factor
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Summary:The aim of this study was to evaluate the clinical importance of fibulin-5, which has been shown to display tumour-promoting and tumour-protective functions in breast lesions. Sixty-two breast cancer patients, 19 patients with fibroadenoma, and 15 healthy breast tissues were enrolled. Forty-seven patients had invasive ductal carcinoma (IDC) (12 of them also had in situ carcinoma DCIS), and 15 had invasive lobular carcinoma (ILC). A scoring system from 0 to 4 was used to evaluate the fibulin-5 staining according to the percentage of stained cells. The median values of fibulin-5 staining scores of the breast cancer, fibroadenoma, and healthy breast tissues were 2 (range: 0-4), 3 (range: 3-4), and 4 (range: 1-4), respectively, and the difference is statistically significant (p = 0.0001). There was no significant difference between the fibulin-5 scores of IDC, ILC, and DCIS. Fifteen patients with triple-negative breast cancer (TNBC) had the lowest fibulin-5 score (p < 0.0001). The median fibulin-5 scores of the patients according to Ki-67 index ≥ 14% and < 14% were 2 (range: 1-5) and 4 (range: 1-5), respectively, and the difference is statistically significant (p = 0.001). These data can be explained by the inhibitory effect of fibulin-5 on epithelial cell proliferation, which is closely related to differentiation and prognosis.
ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2019.93127