Preclinical test of a lentivirus-mediated RNAi gene therapy against HIV-AIDS in the humanized mouse model

Upon removal of shGag5 as in vector R3, transduction of human HPC results in a normal differentiation of the human immune system, highlighting the in vivo safety of this candidate R3 gene therapy vector for a clinical trial. [...] human HPC expressing the antiviral shNef generate human CD4+T cells w...

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Bibliographic Details
Published in:Retrovirology 2011-10, Vol.8 (S2), p.P9-P9, Article P9
Main Authors: Centlivre, Mireille, Legrand, Nicolas, Liu, Ying-Poi, von Eíje, Karin J, Weijer, Kees, Blom, Bianca, Spits, Hergen, Berkhout, Ben
Format: Article
Language:English
Subjects:
Drug resistance
Gene therapy
Poster Presentation
Rodents
Online Access:Get full text
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Summary:Upon removal of shGag5 as in vector R3, transduction of human HPC results in a normal differentiation of the human immune system, highlighting the in vivo safety of this candidate R3 gene therapy vector for a clinical trial. [...] human HPC expressing the antiviral shNef generate human CD4+T cells with the ability to resist HIV-1 replication in a sequence specific manner.
ISSN:1742-4690
1742-4690
DOI:10.1186/1742-4690-8-S2-P9