Ex vivo investigation of glycerol diffusion in skin tissue

The change of optical parameters of rat skin ex vivo under the action of aqueous 30%, 50%, 60%, 70%, 85%, and 100% glycerol solutions has been experimentally studied. The analysis of kinetics of the change of the studied parameters has allowed the estimate of the diffusion coefficient dependence upo...

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Bibliographic Details
Published in:Journal of biomedical photonics & engineering 2016-03, Vol.2 (1), p.10303-10303-5
Main Authors: Genin, Vadim, Tuchina, Daria, Sadeq, Ali Jaafar, Genina, Elina, Tuchin, Valery, Bashkatov, Alexey
Format: Article
Language:English
Subjects:
diffusion coefficient
glycerol
optical clearing
skin
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Summary:The change of optical parameters of rat skin ex vivo under the action of aqueous 30%, 50%, 60%, 70%, 85%, and 100% glycerol solutions has been experimentally studied. The analysis of kinetics of the change of the studied parameters has allowed the estimate of the diffusion coefficient dependence upon the concentration of glycerol in the skin and the efficiency of optical clearing for each of the glycerol solutions. The results can find application in the development of new methods of noninvasive diagnostics and therapy of skin diseases.
ISSN:2411-2844
2411-2844
DOI:10.18287/JBPE16.02.010303