Bleomycin-Induced Fibrosis and the Effectiveness of Centella Asiatica as a Treatment

• Published in: Journal of experimental pharmacology 2024-09, Vol.16, p.311-320
• Main Authors: Soeroso, Noni Novisari, Ichwan, Muhammad, Wahyuni, Arlinda Sari, Mariedina, Causa Trisna, Pakpahan, Yabestin Alfrianus
• Format: Article
• Language: English
• Subjects: Bleomycin; Cancer; Care and treatment; centella asiatica; Chronic diseases; Development and progression; Fibrosis; Lung diseases; Original Research; pulmonary fibrosis; treatment
• ISSN: 1179-1454; 1179-1454
• DOI: 10.2147/JEP.S463899

Plant treatment has been used for thousands of years and has been proven to treat acute and chronic diseases. The function of the traditional plant is as an antimicrobial agent, anticancer, antioxidant, and therapeutic gene in healing wounds and inflammation. Lung fibrosis caused by bleomycin can develop into chronic lung disease, which ends in tissue death if not treated immediately. The purpose of this study is to predict and explain the impact of extract on model rats exposed to bleomycin in their lungs as a treatment or anti-fibrinolysis. This research is an analytical study with a randomized in-vivo experimental design divided into 3 groups of 5 male Wistar rats aged 10 weeks. Negative control group (K) with intratracheal induction of bleomycin alone. The positive group was given intratracheal bleomycin 4 mg/kg/BB on days 0 and 21 and added induction at 400 mg (P1) on days 15 to 49. The other positive group was given intratracheal bleomycin 4 mg/kg/BB on days 0 and 21 and added induction at 800 mg (P2) on days 15 to 49. Data were collected according to findings of lung histology analysis of rat samples. In the interalveolar septum group, there was a difference in Masson's Trichrome staining results in groups K and P1 with p0.05). The induction of bleomycin 4 mg/kg/BB was proven to cause fibrosis in the lungs of rats, and extract was used as a treatment. Therefore, further research regarding antifibrotic drugs is hoped to reduce fibrotic areas significantly.