Effects of Expanded Hemodialysis with Medium Cut-Off Membranes on Maintenance Hemodialysis Patients: A Review

Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most prevalent modality of renal replacement therapy, uses the principle of semipermeable membranes to remove solutes and water in the plasma of patients with kidney failure. With the evolution of hemodialysis technolo...

Full description

Saved in:
Bibliographic Details
Published in:Membranes (Basel) 2022-02, Vol.12 (3), p.253
Main Authors: Zhang, Zhuyun, Yang, Tinghang, Li, Yupei, Li, Jiameng, Yang, Qinbo, Wang, Liya, Jiang, Luojia, Su, Baihai
Format: Article
Language:English
Subjects:
Anemia
artificial kidney
Cardiovascular diseases
Clinical medicine
expanded hemodialysis
Flow velocity
Health risks
Hemodialysis
internal filtration–backfiltration mechanism
Kidney diseases
Kidneys
Maintenance
Malnutrition
Manufacturing
medium cut-off membrane
Membranes
middle molecules
Molecular weight
Morbidity
Morphology
Mortality
Permeability
Physical characteristics
Plasma
Pore size
Proteins
Quality of life
Renal failure
Renal replacement therapy
Retention
Review
Semipermeable membranes
Solutes
Toxins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most prevalent modality of renal replacement therapy, uses the principle of semipermeable membranes to remove solutes and water in the plasma of patients with kidney failure. With the evolution of hemodialysis technology over the last half century, the clearance of small water-soluble molecules in such patients is adequate. However, middle molecules uremic toxins are still retained in the plasma and cause cardiovascular events, anemia, and malnutrition, which significantly contribute to poor quality of life and high mortality in maintenance hemodialysis patients. A new class of membrane, defined as a medium cut-off (MCO) membrane, has emerged in recent years. Expanded hemodialysis with MCO membranes is now recognized as the artificial kidney model closest to natural kidney physiology. This review summarizes the unique morphological characteristics and internal filtration-backfiltration mechanism of MCO membranes, and describes their effects on removing uremic toxins, alleviating inflammation and cardiovascular risk, and improving quality of life in maintenance hemodialysis patients.
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes12030253