MicroRNAs in Human Pituitary Adenomas

MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in p...

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Bibliographic Details
Published in:International Journal of Endocrinology 2014-01, Vol.2014 (2014), p.803-813-085
Main Authors: Yoshimoto, Katsuhiko, Zhou, Hai-Meng, Wang, Elaine Lu, Li, Xu-Hui, Qian, Zhi Rong
Format: Article
Language:English
Subjects:
Cancer
Cell cycle
Development and progression
Endocrinology
Enzymes
Genetic aspects
MicroRNA
MicroRNAs
Mutation
Physiological aspects
Pituitary gland
Pituitary gland tumors
Proteins
Review
Studies
Tumor necrosis factor-TNF
Tumors
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Summary:MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10–15% of diagnosed brain tumors. Deregulated miRNAs and their targets contribute to pituitary adenomas progression and are associated with cell cycle control, apoptosis, invasion, and pharmacological treatment of pituitary adenomas. To provide an overview of miRNAs dysregulation and functions of these miRNAs in pituitary adenoma progression, we summarize the deregulated miRNAs and their targets to shed more light on their potential as therapeutic targets and novel biomarkers.
ISSN:1687-8337
1687-8345
DOI:10.1155/2014/435171