Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions

Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF 3 and PrF 3 nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distri...

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Bibliographic Details
Published in:Nanoscale research letters 2018-11, Vol.13 (1), p.370-24, Article 370
Main Authors: Semashko, Vadim V., Pudovkin, Maksim S., Cefalas, Alkiviadis-Constantinos, Zelenikhin, Pavel V., Gavriil, Vassilios E., Nizamutdinov, Alexei S., Kollia, Zoe, Ferraro, Angelo, Sarantopoulou, Evangelia
Format: Article
Language:English
Subjects:
Activation
Adhesion
Adhesion tests
AKT protein
Binding sites
Cancer
Cancer and nanoparticles
Cell growth
Chemistry and Materials Science
Cytoskeleton
Dipole interactions
Dipoles
Epidermal growth factor receptors
Fluorides
Integrins
Lanthanum fluorides
Ligands
Materials Science
Mechanical stimuli
Mechanosensors
Mechanotransducers
Molecular Medicine
Nano Express
Nanochemistry
Nanoparticles
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Physics of cancer
Rare earth elements
Receptors
Signal transduction
Size distribution
Tumorigenesis
Tumors
Viability
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Summary:Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF 3 and PrF 3 nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR via a synergistic action of an ensemble of tiny size nanoparticles (
ISSN:1931-7573
1556-276X
DOI:10.1186/s11671-018-2775-z