A Novel Framework for Phenotyping Children With Suspected or Confirmed Infection for Future Biomarker Studies

The limited diagnostic accuracy of biomarkers in children at risk of a serious bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed to evaluate the diagnostic performance of a new classification algorithm for biomarker discovery in children at risk of SBI. We u...

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Bibliographic Details
Published in:Frontiers in pediatrics 2021-07, Vol.9, p.688272-688272
Main Authors: Nijman, Ruud G, Oostenbrink, Rianne, Moll, Henriette A, Casals-Pascual, Climent, von Both, Ulrich, Cunnington, Aubrey, De, Tisham, Eleftheriou, Irini, Emonts, Marieke, Fink, Colin, van der Flier, Michiel, de Groot, Ronald, Kaforou, Myrsini, Kohlmaier, Benno, Kuijpers, Taco W, Lim, Emma, Maconochie, Ian K, Paulus, Stephane, Martinon-Torres, Federico, Pokorn, Marko, Romaine, Sam T, Calle, Irene Rivero, Schlapbach, Luregn J, Smit, Frank J, Tsolia, Maria, Usuf, Effua, Wright, Victoria J, Yeung, Shunmay, Zavadska, Dace, Zenz, Werner, Levin, Michael, Herberg, Jethro A, Carrol, Enitan D
Format: Article
Language:English
Subjects:
biomarkers
children
clinical phenotypes
Pediatrics
sepsis
serious bacterial infection
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Summary:The limited diagnostic accuracy of biomarkers in children at risk of a serious bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed to evaluate the diagnostic performance of a new classification algorithm for biomarker discovery in children at risk of SBI. We used data from five previously published, prospective observational biomarker discovery studies, which included patients aged 0-
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2021.688272