Galleria mellonella -A Model for the Study of aPDT-Prospects and Drawbacks

is a promising model insect used for microbiological, medical, and pharmacological research. It provides a platform for testing the biocompatibility of various compounds and the kinetics of survival after an infection followed by subsequent treatment, and for the evaluation of various parameters dur...

Full description

Saved in:
Bibliographic Details
Published in:Microorganisms (Basel) 2023-05, Vol.11 (6), p.1455
Main Authors: Bugyna, Larysa, Kendra, Samuel, Bujdáková, Helena
Format: Article
Language:English
Subjects:
Adaptive immunity
Animals
Antibiotics
Antimicrobial agents
antimicrobial photodynamic therapy
Bacteria
Biocompatibility
Biofilms
Drug resistance
Ethics
Galleria mellonella
Genomes
Gram-negative bacteria
Gram-positive bacteria
Immune response
In vivo methods and tests
Insects
Invertebrates
irradiation
Larvae
larvae infection
Microorganisms
Parasites
Pathogens
Photodynamic therapy
photosensitizer
Probiotics
Review
Reviews
Silver
Streptococcus infections
Toxicity
Vertebrates
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:is a promising model insect used for microbiological, medical, and pharmacological research. It provides a platform for testing the biocompatibility of various compounds and the kinetics of survival after an infection followed by subsequent treatment, and for the evaluation of various parameters during treatment, including the host-pathogen interaction. There are some similarities in the development of pathologies with mammals. However, a limitation is the lack of adaptive immune response. Antimicrobial photodynamic therapy (aPDT) is an alternative approach for combating microbial infections, including biofilm-associated ones. aPDT is effective against Gram-positive and Gram-negative bacteria, viruses, fungi, and parasites, regardless of whether they are resistant to conventional treatment. The main idea of this comprehensive review was to collect information on the use of in aPDT. It provides a collection of references published in the last 10 years from this area of research, complemented by some practical experiences of the authors of this review. Additionally, the review summarizes in brief information on the model, its advantages and methods used in the processing of material from these larvae, as well as basic knowledge of the principles of aPDT.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms11061455