Four New Dicaffeoylquinic Acid Derivatives from Glasswort (Salicornia herbacea L.) and Their Antioxidative Activity

Four new dicaffeoylquinic acid derivatives and two known 3-caffeoylquinic acid derivatives were isolated from methanol extracts using the aerial parts of Salicornia herbacea. The four new dicaffeoylquinic acid derivatives were established as 3-caffeoyl-5-dihydrocaffeoylquinic acid, 3-caffeoyl-5-dihy...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-08, Vol.21 (8), p.1097
Main Authors: Cho, Jeong-Yong, Kim, Jin Young, Lee, Yu Geon, Lee, Hyoung Jae, Shim, Hyun Jeong, Lee, Ji Hye, Kim, Seon-Jae, Ham, Kyung-Sik, Moon, Jae-Hak
Format: Article
Language:English
Subjects:
Animals
antioxidant
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
blood plasma oxidation
caffeoylquinic acid derivatives
Chenopodiaceae - chemistry
Magnetic Resonance Spectroscopy
Male
Molecular Structure
Oxidative Stress - drug effects
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plasma - chemistry
Plasma - drug effects
Quinic Acid - analogs & derivatives
Quinic Acid - chemistry
Quinic Acid - pharmacology
radical-scavenging activity
Rats
Salicornia herbacea
Spectrometry, Mass, Electrospray Ionization
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Summary:Four new dicaffeoylquinic acid derivatives and two known 3-caffeoylquinic acid derivatives were isolated from methanol extracts using the aerial parts of Salicornia herbacea. The four new dicaffeoylquinic acid derivatives were established as 3-caffeoyl-5-dihydrocaffeoylquinic acid, 3-caffeoyl-5-dihydrocaffeoylquinic acid methyl ester, 3-caffeoyl-4-dihydrocaffeoylquinic acid methyl ester, and 3,5-di-dihydrocaffeoylquinic acid methyl ester. Their chemical structures were determined by nuclear magnetic resonance and electrospray ionization-mass spectroscopy (LC-ESI-MS). In addition, the presence of dicaffeoylquinic acid derivatives in this plant was reconfirmed by LC-ESI-MS/MS analysis. The isolated compounds strongly scavenged 1,1-diphenyl-2-picrylhydrazyl radicals and inhibited cholesteryl ester hydroperoxide formation during rat blood plasma oxidation induced by copper ions. These results indicate that the caffeoylquinic acid derivatives may partially contribute to the antioxidative effect of S. herbacea.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21081097