SUMOylation of spastin promotes the internalization of GluA1 and regulates dendritic spine morphology by targeting microtubule dynamics

Dendritic spines are specialized structures involved in neuronal processes on which excitatory synaptic contact occurs. The microtubule cytoskeleton is vital for maintaining spine morphology and mature synapses. Spastin is related to microtubule-severing proteases and is involved in synaptic bouton...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiology of disease 2020-12, Vol.146, p.105133-105133, Article 105133
Main Authors: Ji, Zhi-Sheng, Liu, Qiu-Ling, Zhang, Ji-feng, Yang, Yu-Hao, Li, Jiong, Zhang, Guo-Wei, Tan, Ming-Hui, Lin, Hong-Sheng, Guo, Guo-Qing
Format: Article
Language:English
Subjects:
Dendritic spine
GluA1 internalization
Microtubule dynamics
Spastin
SUMOylation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dendritic spines are specialized structures involved in neuronal processes on which excitatory synaptic contact occurs. The microtubule cytoskeleton is vital for maintaining spine morphology and mature synapses. Spastin is related to microtubule-severing proteases and is involved in synaptic bouton formation. However, it is not yet known if spastin can be modified by Small Ubiquitin-like Modifier (SUMO) or how this modification regulates dendritic spines. Spastin was shown to be SUMOylated at K427, and its deSUMOylation promoted microtubule stability. In addition, SUMOylation of spastin was shown to affect signalling pathways associated with long term synaptic depression. SUMOylated spastin promoted the development of dendrites and dendritic spines. Moreover, SUMOylated spastin regulated endocytosis and affected the transport of the AMPA receptor, GluA1. Our findings suggest that SUMOylation of spastin promotes GluA1 internalization and regulates dendritic spine morphology through targeting of microtubule dynamics. [Display omitted] •Spastin was SUMOylated at K427.•SUMOylated spastin promoted the development of dendrites and dendritic spines by targeting microtubule dynamics.•SUMOylated spastin regulates endocytosis and affects the transport of GluA1.
ISSN:0969-9961
1095-953X
DOI:10.1016/j.nbd.2020.105133