Anti-metastatic effect of methylprednisolone targeting vascular endothelial cells under surgical stress

Perioperative systemic inflammation induced by surgical stress elevates the risk of hematogenous cancer metastasis. This study investigated the anti-metastatic effects and mechanisms of methylprednisolone (MP) administration for surgical stress. We examined the effects of MP on the expression of adh...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2021-03, Vol.11 (1), p.6268-6268, Article 6268
Main Authors: Hagi, Takaomi, Kurokawa, Yukinori, Kobayashi, Noboru, Takahashi, Tsuyoshi, Saito, Takuro, Yamashita, Kotaro, Tanaka, Koji, Makino, Tomoki, Yamasaki, Makoto, Nakajima, Kiyokazu, Eguchi, Hidetoshi, Doki, Yuichiro
Format: Article
Language:English
Subjects:
631/67/1504/1829
631/67/322
631/67/327
Adhesion
Cancer
Cell adhesion molecules
E-selectin
Endothelial cells
Endothelium
Gastric cancer
Humanities and Social Sciences
Inflammation
Lipopolysaccharides
Liver
Metastases
Metastasis
Methylprednisolone
multidisciplinary
Portal vein
Science
Science (multidisciplinary)
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Perioperative systemic inflammation induced by surgical stress elevates the risk of hematogenous cancer metastasis. This study investigated the anti-metastatic effects and mechanisms of methylprednisolone (MP) administration for surgical stress. We examined the effects of MP on the expression of adhesion molecules in human vascular endothelial cells and in a murine hepatic metastasis model under lipopolysaccharide (LPS) administration, which mimics systemic inflammation induced by surgical stress. Serum E-selectin level was measured in blood samples obtained from 32 gastric cancer patients who were randomly assigned to treat preoperatively with or without MP. The expression of E-selectin in LPS-induced vascular endothelial cells was suppressed by MP. An adhesion assay showed the number of LPS-induced adherent tumour cells was significantly lower following MP. In the in vivo study, LPS significantly elevated the number of hepatic metastases, but pretreatment with MP before LPS significantly inhibited this elevation. The LPS-induced expression of E-selectin in the vascular endothelium of the portal vein was suppressed by MP. In human clinical samples, serum E-selectin level was significantly decreased by preoperative MP. Suppression of surgically induced systemic inflammation by MP administration might prevent hematogenous cancer metastases by suppressing the induction of E-selectin expression in the vascular endothelium.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-85241-2