Conflicting Roles of 20-HETE in Hypertension and Stroke

Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endot...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2019-09, Vol.20 (18), p.4500
Main Authors: Shekhar, Shashank, Varghese, Kevin, Li, Man, Fan, Letao, Booz, George W, Roman, Richard J, Fan, Fan
Format: Article
Language:English
Subjects:
Acids
Angiogenesis
Animals
Arteries
Blood pressure
blood-brain barrier
Calcium
Cell growth
Cell proliferation
cerebral autoregulation
cytochrome P450
Disease Progression
endothelial dysfunction
Enzymes
Humans
Hydroxyeicosatetraenoic Acids - metabolism
Hypertension
Hypertension - metabolism
Inflammation
Insulin
Insulin secretion
Islet cells
Kinases
Metabolism
Metabolites
Models, Biological
Muscles
Oxidative stress
Pancreas
Pathogenesis
Polymorphism, Genetic
Protein kinase C
Proteins
Restenosis
Review
Roles
Smooth muscle
Sodium
Stroke
Stroke - metabolism
Traumatic brain injury
Tyrosine
vascular inflammation
vascular remodeling
Vasodilation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypertension is the most common modifiable risk factor for stroke, and understanding the underlying mechanisms of hypertension and hypertension-related stroke is crucial. 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE), which plays an important role in vasoconstriction, autoregulation, endothelial dysfunction, angiogenesis, inflammation, and blood-brain barrier integrity, has been linked to hypertension and stroke. 20-HETE can promote hypertension by potentiating the vascular response to vasoconstrictors; it also can reduce blood pressure by inhibition of sodium transport in the kidney. The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in and that reduce 20-HETE production are more susceptible to stroke. This review summarizes recent genetic variants in and influencing 20-HETE production and discusses the role of 20-HETE in hypertension and the susceptibility to the onset, progression, and prognosis of ischemic and hemorrhagic strokes.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20184500