The influence of end-stage liver disease and liver transplantation on thyroid hormones

Thyroid dysfunction has been reported in most chronic illnesses including severe liver disease. These defects in thyroid hormone metabolism result in the sick euthyroid syndrome, also known as low T3 syndrome. Our objective was to evaluate the thyroid function in patients with end stage liver diseas...

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Bibliographic Details
Published in:Arquivos de gastroenterologia 2015-06, Vol.52 (2), p.124-128
Main Authors: Penteado, Karla Rocha, Coelho, Júlio Cezar Uili, Parolin, Mônica Beatriz, Matias, Jorge Eduardo Fouto, Freitas, Alexandre Coutinho Teixeira de
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
End stage liver disease
End Stage Liver Disease - blood
End Stage Liver Disease - physiopathology
End Stage Liver Disease - surgery
Euthyroid sick syndromes
Female
GASTROENTEROLOGY & HEPATOLOGY
Humans
Liver cirrhosis
Liver Transplantation
Male
Middle Aged
Prospective Studies
Severity of Illness Index
Thyroid Gland - physiopathology
Thyroid Hormones - blood
Thyrotropin
Thyrotropin - blood
Thyroxine
Thyroxine - blood
Triiodothyronine
Triiodothyronine - blood
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Summary:Thyroid dysfunction has been reported in most chronic illnesses including severe liver disease. These defects in thyroid hormone metabolism result in the sick euthyroid syndrome, also known as low T3 syndrome. Our objective was to evaluate the thyroid function in patients with end stage liver disease prior and after deceased donor liver transplantation and to correlate thyroid hormonal changes with the MELD score (Model for End stage Liver Disease). In a prospective study, serum levels of thyrotropin (thyroid stimulating hormone TSH), total thyroxine (tT4), free thyroxine (fT4) and triiodothyronine (T3) from 30 male adult patients with end stage liver disease were measured two to four hours before and 6 months after liver transplantation (LT). MELD was determined on the day of transplant. For this analysis, extra points were not added for patients with hepatocellular carcinoma. The patients had normal TSH and fT4 levels before LT and there was no change after the procedure. Total thyroxine and triiodothyronine were within the normal range before LT, except for four patients (13.3%) whose values were lower. Both hormones increased to normal values in all four patients after LT (P=0.02 and P
ISSN:0004-2803
1678-4219
1678-4219
0004-2803
DOI:10.1590/S0004-28032015000200009