Audiovisual spatial recalibration but not integration is shaped by early sensory experience

To clarify the role of sensory experience during early development for adult multisensory learning capabilities, we probed audiovisual spatial processing in human individuals who had been born blind because of dense congenital cataracts (CCs) and who subsequently had received cataract removal surger...

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Bibliographic Details
Published in:iScience 2022-06, Vol.25 (6), p.104439, Article 104439
Main Authors: Bruns, Patrick, Li, Lux, Guerreiro, Maria J.S., Shareef, Idris, Rajendran, Siddhart S., Pitchaimuthu, Kabilan, Kekunnaya, Ramesh, Röder, Brigitte
Format: Article
Language:English
Subjects:
Cognitive neuroscience
Developmental neuroscience
Ophthalmology
Optometri
Optometry
Sensory neuroscience
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Summary:To clarify the role of sensory experience during early development for adult multisensory learning capabilities, we probed audiovisual spatial processing in human individuals who had been born blind because of dense congenital cataracts (CCs) and who subsequently had received cataract removal surgery, some not before adolescence or adulthood. Their ability to integrate audio-visual input and to recalibrate multisensory spatial representations was compared to normally sighted control participants and individuals with a history of developmental (later onset) cataracts. Results in CC individuals revealed both normal multisensory integration in audiovisual trials (ventriloquism effect) and normal recalibration of unimodal auditory localization following audiovisual discrepant exposure (ventriloquism aftereffect) as observed in the control groups. In addition, only the CC group recalibrated unimodal visual localization after audiovisual exposure. Thus, in parallel to typical multisensory integration and learning, atypical crossmodal mechanisms coexisted in CC individuals, suggesting that multisensory recalibration capabilities are defined during a sensitive period in development. [Display omitted] •Audiovisual spatial processing recovers after congenital cataract removal surgery•Long durations of congenital blindness do not prevent recovery•Sight-recovery individuals use audiovisual input to recalibrate visual localization•Typical and atypical crossmodal mechanisms coexist after sight recovery Ophthalmology; Developmental neuroscience; Sensory neuroscience; Cognitive neuroscience
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2022.104439