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Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database
Background Carcinosarcomas are rare, aggressive malignancies that can arise in the nasal cavity and paranasal sinuses. There are limited outcome data available. Accordingly, we sought to use the National Cancer Database (NCDB) to characterize patient demographics and outcomes. Method A retrospective...
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| Published in: | World journal of otorhinolaryngology - head and neck surgery 2023-06, Vol.9 (2), p.115-122 |
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| container_title | World journal of otorhinolaryngology - head and neck surgery |
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| creator | Harris, Jacob C. Eide, Jacob G. Kshirsagar, Rijul S. Brant, Jason A. Palmer, James N. Adappa, Nithin D. |
| description | Background
Carcinosarcomas are rare, aggressive malignancies that can arise in the nasal cavity and paranasal sinuses. There are limited outcome data available. Accordingly, we sought to use the National Cancer Database (NCDB) to characterize patient demographics and outcomes.
Method
A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted.
Results
Thirty patients were included. The patients were predominantly male (n = 20), white (n = 23), and privately insured (n = 15), with an average age of 62.4 years. The nasal cavity was the most common subsite (n = 14), followed by the maxillary sinus (n = 8). Most patient were treated with surgery followed by radiation (n = 23), with the remaining undergoing surgery alone (n = 4), radiation alone (n = 2), or no treatment (n = 1). One‐third (n = 10) received adjuvant chemotherapy. The 1‐ and 5‐year overall survival (OS) in the cohort were 79.2% and 43.3%, respectively. Univariate log‐rank testing showed OS varied based on intervention (P |
| doi_str_mv | 10.1002/wjo2.82 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_723a8ddf4349418f9c41734d30707ca6</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_723a8ddf4349418f9c41734d30707ca6</doaj_id><sourcerecordid>3090902008</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5002-6c1165b1e06ded6c00dc257986fb3b624d6b1cd6d914334c0065c29c59a294153</originalsourceid><addsrcrecordid>eNp1kl1rFDEUhoMotrTFfyADXliQqfmYZBJvpCx-VAoFUbyMZ5JMm2U2WZOZXfbfm-201QqSixPOec7Le5KD0AuCzwjG9O12GemZpE_QIeVS1QRL8rTcseK1lIQcoJOcfYcbygTDnD9HB6xlkjHWHKKfC0jGh5hLiCuoYl-NN64KkGGoDGz8uKsg2GoNCeZk9mHKLr-rvrqNd9s_HaOP4bYpGJcqCyN0kN0xetbDkN3JXTxC3z9--Lb4XF9efbpYnF_WhpcZamEIEbwjDgvrrDAYW0N5q6ToO9YJ2ljREWOFVaQpxktdcEOV4QqoaghnR-hi1rURlnqd_ArSTkfw-jYR07WGNHozON1SBtLavmFNaZW9Mg1pWWMZbnFrQBSt97PWeupWzhoXxgTDI9HHleBv9HXcaIKpEpjt3ZzeKaT4a3J51CufjRsGCC5OWVPJCFWKMFLQV_-gyzil8pJZM6zKoRjLQr2eKZNizsn1D24I1vst0Pst0JIW8uXf5h-4-z8vwJsZ2PrB7f6no398uaJF7jcOXLm0</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090902008</pqid></control><display><type>article</type><title>Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database</title><source>PubMed (Medline)</source><source>Publicly Available Content (ProQuest)</source><source>Wiley Open Access</source><creator>Harris, Jacob C. ; Eide, Jacob G. ; Kshirsagar, Rijul S. ; Brant, Jason A. ; Palmer, James N. ; Adappa, Nithin D.</creator><creatorcontrib>Harris, Jacob C. ; Eide, Jacob G. ; Kshirsagar, Rijul S. ; Brant, Jason A. ; Palmer, James N. ; Adappa, Nithin D.</creatorcontrib><description>Background
Carcinosarcomas are rare, aggressive malignancies that can arise in the nasal cavity and paranasal sinuses. There are limited outcome data available. Accordingly, we sought to use the National Cancer Database (NCDB) to characterize patient demographics and outcomes.
Method
A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted.
Results
Thirty patients were included. The patients were predominantly male (n = 20), white (n = 23), and privately insured (n = 15), with an average age of 62.4 years. The nasal cavity was the most common subsite (n = 14), followed by the maxillary sinus (n = 8). Most patient were treated with surgery followed by radiation (n = 23), with the remaining undergoing surgery alone (n = 4), radiation alone (n = 2), or no treatment (n = 1). One‐third (n = 10) received adjuvant chemotherapy. The 1‐ and 5‐year overall survival (OS) in the cohort were 79.2% and 43.3%, respectively. Univariate log‐rank testing showed OS varied based on intervention (P < 0.029), sex (P < 0.042), and age (P < 0.025), while on multivariate analysis none of these factors independently predicted OS.
Conclusions
We describe the demographics and presenting features of a national cohort of sinonasal carcinosarcoma patients. Future research is needed to identify predictors of overall survival, and to assess the optimal roles for radiation and systemic chemotherapy.
Highlights
The demographics and outcomes for a cohort of 30 patients with sinonasal carcinosarcoma were described.
Seventy‐six percent of patients were treated with surgery followed by adjuvant radiotherapy.
1‐ and 5‐year survival from the time of diagnosis were 79.2% and 43.3% respectively.
Neither surgical intervention, patient sex, nor patient age independently predicted survival outcomes.</description><identifier>ISSN: 2095-8811</identifier><identifier>EISSN: 2589-1081</identifier><identifier>DOI: 10.1002/wjo2.82</identifier><identifier>PMID: 37383334</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Age ; cancer ; Cancer therapies ; carcinosarcoma ; Case reports ; Chemotherapy ; Comorbidity ; Demographics ; Endoscopy ; Histology ; Hospitals ; Length of stay ; Medicaid ; Medical prognosis ; Medicare ; National Cancer Database ; NCDB ; outcomes ; Patients ; Radiation therapy ; Review ; sinonasal ; Sinuses ; Statistical analysis ; Surgery ; survival ; Tumors</subject><ispartof>World journal of otorhinolaryngology - head and neck surgery, 2023-06, Vol.9 (2), p.115-122</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.</rights><rights>2022 The Authors. World Journal of Otorhinolaryngology ‐ Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.</rights><rights>2023. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5002-6c1165b1e06ded6c00dc257986fb3b624d6b1cd6d914334c0065c29c59a294153</citedby><cites>FETCH-LOGICAL-c5002-6c1165b1e06ded6c00dc257986fb3b624d6b1cd6d914334c0065c29c59a294153</cites><orcidid>0000-0001-6811-626X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10296035/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3090902008?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11561,25752,27923,27924,37011,37012,44589,46051,46475,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37383334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, Jacob C.</creatorcontrib><creatorcontrib>Eide, Jacob G.</creatorcontrib><creatorcontrib>Kshirsagar, Rijul S.</creatorcontrib><creatorcontrib>Brant, Jason A.</creatorcontrib><creatorcontrib>Palmer, James N.</creatorcontrib><creatorcontrib>Adappa, Nithin D.</creatorcontrib><title>Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database</title><title>World journal of otorhinolaryngology - head and neck surgery</title><addtitle>World J Otorhinolaryngol Head Neck Surg</addtitle><description>Background
Carcinosarcomas are rare, aggressive malignancies that can arise in the nasal cavity and paranasal sinuses. There are limited outcome data available. Accordingly, we sought to use the National Cancer Database (NCDB) to characterize patient demographics and outcomes.
Method
A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted.
Results
Thirty patients were included. The patients were predominantly male (n = 20), white (n = 23), and privately insured (n = 15), with an average age of 62.4 years. The nasal cavity was the most common subsite (n = 14), followed by the maxillary sinus (n = 8). Most patient were treated with surgery followed by radiation (n = 23), with the remaining undergoing surgery alone (n = 4), radiation alone (n = 2), or no treatment (n = 1). One‐third (n = 10) received adjuvant chemotherapy. The 1‐ and 5‐year overall survival (OS) in the cohort were 79.2% and 43.3%, respectively. Univariate log‐rank testing showed OS varied based on intervention (P < 0.029), sex (P < 0.042), and age (P < 0.025), while on multivariate analysis none of these factors independently predicted OS.
Conclusions
We describe the demographics and presenting features of a national cohort of sinonasal carcinosarcoma patients. Future research is needed to identify predictors of overall survival, and to assess the optimal roles for radiation and systemic chemotherapy.
Highlights
The demographics and outcomes for a cohort of 30 patients with sinonasal carcinosarcoma were described.
Seventy‐six percent of patients were treated with surgery followed by adjuvant radiotherapy.
1‐ and 5‐year survival from the time of diagnosis were 79.2% and 43.3% respectively.
Neither surgical intervention, patient sex, nor patient age independently predicted survival outcomes.</description><subject>Age</subject><subject>cancer</subject><subject>Cancer therapies</subject><subject>carcinosarcoma</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Comorbidity</subject><subject>Demographics</subject><subject>Endoscopy</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Length of stay</subject><subject>Medicaid</subject><subject>Medical prognosis</subject><subject>Medicare</subject><subject>National Cancer Database</subject><subject>NCDB</subject><subject>outcomes</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>sinonasal</subject><subject>Sinuses</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>survival</subject><subject>Tumors</subject><issn>2095-8811</issn><issn>2589-1081</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp1kl1rFDEUhoMotrTFfyADXliQqfmYZBJvpCx-VAoFUbyMZ5JMm2U2WZOZXfbfm-201QqSixPOec7Le5KD0AuCzwjG9O12GemZpE_QIeVS1QRL8rTcseK1lIQcoJOcfYcbygTDnD9HB6xlkjHWHKKfC0jGh5hLiCuoYl-NN64KkGGoDGz8uKsg2GoNCeZk9mHKLr-rvrqNd9s_HaOP4bYpGJcqCyN0kN0xetbDkN3JXTxC3z9--Lb4XF9efbpYnF_WhpcZamEIEbwjDgvrrDAYW0N5q6ToO9YJ2ljREWOFVaQpxktdcEOV4QqoaghnR-hi1rURlnqd_ArSTkfw-jYR07WGNHozON1SBtLavmFNaZW9Mg1pWWMZbnFrQBSt97PWeupWzhoXxgTDI9HHleBv9HXcaIKpEpjt3ZzeKaT4a3J51CufjRsGCC5OWVPJCFWKMFLQV_-gyzil8pJZM6zKoRjLQr2eKZNizsn1D24I1vst0Pst0JIW8uXf5h-4-z8vwJsZ2PrB7f6no398uaJF7jcOXLm0</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Harris, Jacob C.</creator><creator>Eide, Jacob G.</creator><creator>Kshirsagar, Rijul S.</creator><creator>Brant, Jason A.</creator><creator>Palmer, James N.</creator><creator>Adappa, Nithin D.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6811-626X</orcidid></search><sort><creationdate>202306</creationdate><title>Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database</title><author>Harris, Jacob C. ; Eide, Jacob G. ; Kshirsagar, Rijul S. ; Brant, Jason A. ; Palmer, James N. ; Adappa, Nithin D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5002-6c1165b1e06ded6c00dc257986fb3b624d6b1cd6d914334c0065c29c59a294153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>cancer</topic><topic>Cancer therapies</topic><topic>carcinosarcoma</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Comorbidity</topic><topic>Demographics</topic><topic>Endoscopy</topic><topic>Histology</topic><topic>Hospitals</topic><topic>Length of stay</topic><topic>Medicaid</topic><topic>Medical prognosis</topic><topic>Medicare</topic><topic>National Cancer Database</topic><topic>NCDB</topic><topic>outcomes</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Review</topic><topic>sinonasal</topic><topic>Sinuses</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Jacob C.</creatorcontrib><creatorcontrib>Eide, Jacob G.</creatorcontrib><creatorcontrib>Kshirsagar, Rijul S.</creatorcontrib><creatorcontrib>Brant, Jason A.</creatorcontrib><creatorcontrib>Palmer, James N.</creatorcontrib><creatorcontrib>Adappa, Nithin D.</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Free Archive</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>World journal of otorhinolaryngology - head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, Jacob C.</au><au>Eide, Jacob G.</au><au>Kshirsagar, Rijul S.</au><au>Brant, Jason A.</au><au>Palmer, James N.</au><au>Adappa, Nithin D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database</atitle><jtitle>World journal of otorhinolaryngology - head and neck surgery</jtitle><addtitle>World J Otorhinolaryngol Head Neck Surg</addtitle><date>2023-06</date><risdate>2023</risdate><volume>9</volume><issue>2</issue><spage>115</spage><epage>122</epage><pages>115-122</pages><issn>2095-8811</issn><eissn>2589-1081</eissn><abstract>Background
Carcinosarcomas are rare, aggressive malignancies that can arise in the nasal cavity and paranasal sinuses. There are limited outcome data available. Accordingly, we sought to use the National Cancer Database (NCDB) to characterize patient demographics and outcomes.
Method
A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was conducted.
Results
Thirty patients were included. The patients were predominantly male (n = 20), white (n = 23), and privately insured (n = 15), with an average age of 62.4 years. The nasal cavity was the most common subsite (n = 14), followed by the maxillary sinus (n = 8). Most patient were treated with surgery followed by radiation (n = 23), with the remaining undergoing surgery alone (n = 4), radiation alone (n = 2), or no treatment (n = 1). One‐third (n = 10) received adjuvant chemotherapy. The 1‐ and 5‐year overall survival (OS) in the cohort were 79.2% and 43.3%, respectively. Univariate log‐rank testing showed OS varied based on intervention (P < 0.029), sex (P < 0.042), and age (P < 0.025), while on multivariate analysis none of these factors independently predicted OS.
Conclusions
We describe the demographics and presenting features of a national cohort of sinonasal carcinosarcoma patients. Future research is needed to identify predictors of overall survival, and to assess the optimal roles for radiation and systemic chemotherapy.
Highlights
The demographics and outcomes for a cohort of 30 patients with sinonasal carcinosarcoma were described.
Seventy‐six percent of patients were treated with surgery followed by adjuvant radiotherapy.
1‐ and 5‐year survival from the time of diagnosis were 79.2% and 43.3% respectively.
Neither surgical intervention, patient sex, nor patient age independently predicted survival outcomes.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>37383334</pmid><doi>10.1002/wjo2.82</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6811-626X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); Publicly Available Content (ProQuest); Wiley Open Access |
| subjects | Age cancer Cancer therapies carcinosarcoma Case reports Chemotherapy Comorbidity Demographics Endoscopy Histology Hospitals Length of stay Medicaid Medical prognosis Medicare National Cancer Database NCDB outcomes Patients Radiation therapy Review sinonasal Sinuses Statistical analysis Surgery survival Tumors |
| title | Carcinosarcoma of the nasal cavity and paranasal sinuses: Review of the national cancer database |
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