Development and evaluation of nanostructured lipid carrier-based hydrogel for topical delivery of 5-fluorouracil

The aim of this study was to develop a nanostructured lipid carrier (NLC)-based hydrogel and study its potential for the topical delivery of 5-fluorouracil (5-FU). Precirol ATO 5 (glyceryl palmitostearate) and Labrasol were selected as the solid and liquid lipid phases, respectively. Poloxamer 188 a...

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Bibliographic Details
Published in:International journal of nanomedicine 2016-01, Vol.11, p.5067-5077
Main Authors: Rajinikanth, Paruvathanahalli Siddalingam, Chellian, Jestin
Format: Article
Language:English
Subjects:
5-Fluoruracil
Acrylic acid
Administration, Topical
Analysis
Animals
Antimetabolites, Antineoplastic - administration & dosage
Chemistry, Pharmaceutical
Controlled release
Drug Carriers - administration & dosage
Drug Carriers - chemistry
Drug Delivery Systems
Drug Design
Drugs
Erythema - metabolism
Erythema - prevention & control
Fluorouracil
Fluorouracil - administration & dosage
Hydration
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogels
Lipids
Lipids - chemistry
Male
Mice
Microscopy, Electron, Transmission
Nanoemulsions
Nanoparticles
Nanostructure lipid carrier
Nanostructures - chemistry
Original Research
Particle Size
Pharmacy
Rats
Rats, Wistar
Retention
Skin - drug effects
Skin - metabolism
Skin Absorption - drug effects
Skin Absorption - radiation effects
Skin infection
Skin Penetration
Topical delivery
Transdermal drug delivery systems
Transdermal medication
Vehicles
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Summary:The aim of this study was to develop a nanostructured lipid carrier (NLC)-based hydrogel and study its potential for the topical delivery of 5-fluorouracil (5-FU). Precirol ATO 5 (glyceryl palmitostearate) and Labrasol were selected as the solid and liquid lipid phases, respectively. Poloxamer 188 and Solutol HS15 (polyoxyl-15-hydroxystearate) were selected as surfactants. The developed lipid formulations were dispersed in 1% Carbopol 934 (poly[acrylic acid]) gel medium in order to maintain the topical application consistency. The average size, zeta potential, and polydispersity index for the 5-FU-NLC were found to be 208.32±8.21 nm, -21.82±0.40 mV, and 0.352±0.060, respectively. Transmission electron microscopy study revealed that 5-FU-NLC was
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S117511