The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis

Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. In addition, the patie...

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Bibliographic Details
Published in:Journal of ophthalmology 2024-01, Vol.2024, p.6416773-14
Main Authors: Chu, Liyuan, Bi, Chaoran, Wang, Caiming, Zhou, Hongyan
Format: Article
Language:English
Subjects:
Apoptosis
Blood vessels
Cardiovascular diseases
Development and progression
Enzymes
Fatty acids
Inflammation
Macular degeneration
Microbiota (Symbiotic organisms)
Mitochondria
Mitochondrial DNA
Oxidation
Oxidative stress
Pathogenesis
Pathogens
Phosphorylation
Photoreceptors
Proteins
Retina
Review
Transcription factors
Visual acuity
Wu, K. C
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Summary:Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. In addition, the patient’s genes, age, gender, cardiovascular disease, unhealthy diet, and living habits may also be risk factors for this disease. Complement proteins are widely distributed in serum and tissue fluid. In the early 21st century, a connection was found between the complement cascade and age-related macular degeneration. However, little is known about the effect of complement factors on the pathogenesis of age-related macular degeneration. This article reviews the factors associated with age-related macular degeneration, the relationship between each factor and complement, the related functions, and variants and provides new ideas for the treatment of this disease.
ISSN:2090-004X
2090-0058
DOI:10.1155/2024/6416773