A New Age-Structured Multiscale Model of the Hepatitis C Virus Life-Cycle During Infection and Therapy With Direct-Acting Antiviral Agents

The dynamics of hepatitis C virus (HCV) RNA during translation and replication within infected cells were added to a previous age-structured multiscale mathematical model of HCV infection and treatment. The model allows the study of the dynamics of HCV RNA inside infected cells as well as the releas...

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Bibliographic Details
Published in:Frontiers in microbiology 2018-04, Vol.9, p.601-601
Main Authors: Quintela, Barbara de M, Conway, Jessica M, Hyman, James M, Guedj, Jeremie, Dos Santos, Rodrigo W, Lobosco, Marcelo, Perelson, Alan S
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Biological Science
computational biology
DAAs
differential equations
HCV
Microbiology
RNA
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Summary:The dynamics of hepatitis C virus (HCV) RNA during translation and replication within infected cells were added to a previous age-structured multiscale mathematical model of HCV infection and treatment. The model allows the study of the dynamics of HCV RNA inside infected cells as well as the release of virus from infected cells and the dynamics of subsequent new cell infections. The model was used to fit data and estimate parameters characterizing HCV replication. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-structured multiscale modeling approach. Using this model we also studied the effects of direct-acting antiviral agents (DAAs) in blocking HCV RNA intracellular replication and the release of new virions and fit the model to data obtained from HCV-infected subjects under therapy.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2018.00601