Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome

This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 19), we me...

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Published in:Scientific reports 2021-08, Vol.11 (1), p.17315-17315, Article 17315
Main Authors: Sakuma, Masashi, Nishino, Setsu, Nasuno, Takahisa, Kageyama, Michiya, Tokura, Michiaki, Sohma, Ryoichi, Inoue, Ken-ichi, Kanaya, Tomoaki, Obi, Syotaro, Toyoda, Shigeru, Abe, Shichiro, Attizzani, Guiherme F., Pereira, Gabriel T. R., Bezerra, Hiram G., Inoue, Teruo
Format: Article
Language:English
Subjects:
692/4019/2776
692/4019/592
Acute coronary syndromes
CD34 antigen
Humanities and Social Sciences
Implants
multidisciplinary
Progenitor cells
Science
Science (multidisciplinary)
Stem cells
Stents
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Summary:This study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 19), we measured circulating CD34+/CD133+/CD45 null cells and CD34+/KDR+ cells and observed vascular healing at the stented sites using optical coherence tomography (OCT) and coronary angioscopy. On the day 7, circulating CD34+/CD133+/CD45 null cells increased in SYNERGY group ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96730-9