A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)

We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors, and describe the clinical cascade among children aged < 15 yea...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-11, Vol.17 (11), p.e0277613
Main Authors: Immaculate Mutisya, Evelyn Muthoni, Raphael O Ondondo, Jacques Muthusi, Lennah Omoto, Charlotte Pahe, Abraham Katana, Evelyn Ngugi, Kenneth Masamaro, Leonard Kingwara, Trudy Dobbs, Megan Bronson, Hetal K Patel, Nicholas Sewe, Doris Naitore, Kevin De Cock, Catherine Ngugi, Lucy Nganga
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 11
container_start_page e0277613
container_title PloS one
container_volume 17
creator Immaculate Mutisya
Evelyn Muthoni
Raphael O Ondondo
Jacques Muthusi
Lennah Omoto
Charlotte Pahe
Abraham Katana
Evelyn Ngugi
Kenneth Masamaro
Leonard Kingwara
Trudy Dobbs
Megan Bronson
Hetal K Patel
Nicholas Sewe
Doris Naitore
Kevin De Cock
Catherine Ngugi
Lucy Nganga
description We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors, and describe the clinical cascade among children aged < 15 years in Kenya. Interviewers collected information from caregivers or guardians on child's demographics, HIV testing, and treatment history. Blood specimens were collected for HIV serology and if HIV-positive, the samples were tested for viral load and antiretrovirals (ARV). For participants
doi_str_mv 10.1371/journal.pone.0277613
format article
fullrecord <record><control><sourceid>doaj</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_7273aa38553c423fb4959dec4d92ed0a</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_7273aa38553c423fb4959dec4d92ed0a</doaj_id><sourcerecordid>oai_doaj_org_article_7273aa38553c423fb4959dec4d92ed0a</sourcerecordid><originalsourceid>FETCH-LOGICAL-d1021-6a1fbb67836c7d02b20b448c9793510611601fdc293adba6afa82e978c0793c53</originalsourceid><addsrcrecordid>eNotjEtOwzAURS0kJEphBwzeEAYp_iT-DKuKT0UlJsA0erGd1lVqV05bKUtgH6yMlRABoysdnXMJuWF0xoRi99t0zBG72T5FP6NcKcnEGZkwI3ghORUX5LLvt5RWQks5IXkOEQ8hjQls0rH3m9Q56I_55AdIEZ6XH7DP_oSdj9YDRge2CzHY0bfYW3Qj3KW4BrsJncs-Aq69g-_PL1bB4DH3ECK8-Dgg3HLK9N0VOW-x6_31_07J--PD2-K5WL0-LRfzVeEY5ayQyNqmkUoLaZWjvOG0KUttjTKiYlQyJilrneVGoGtQYouae6O0paNhKzEly79fl3Bb73PYYR7qhKH-BSmva8yHYDtfK64EotBVJWzJRduUpjLO29IZ7h1F8QMlPmm2</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)</title><source>Access via ProQuest (Open Access)</source><source>PubMed Central</source><creator>Immaculate Mutisya ; Evelyn Muthoni ; Raphael O Ondondo ; Jacques Muthusi ; Lennah Omoto ; Charlotte Pahe ; Abraham Katana ; Evelyn Ngugi ; Kenneth Masamaro ; Leonard Kingwara ; Trudy Dobbs ; Megan Bronson ; Hetal K Patel ; Nicholas Sewe ; Doris Naitore ; Kevin De Cock ; Catherine Ngugi ; Lucy Nganga</creator><creatorcontrib>Immaculate Mutisya ; Evelyn Muthoni ; Raphael O Ondondo ; Jacques Muthusi ; Lennah Omoto ; Charlotte Pahe ; Abraham Katana ; Evelyn Ngugi ; Kenneth Masamaro ; Leonard Kingwara ; Trudy Dobbs ; Megan Bronson ; Hetal K Patel ; Nicholas Sewe ; Doris Naitore ; Kevin De Cock ; Catherine Ngugi ; Lucy Nganga</creatorcontrib><description>We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors, and describe the clinical cascade among children aged &lt; 15 years in Kenya. Interviewers collected information from caregivers or guardians on child's demographics, HIV testing, and treatment history. Blood specimens were collected for HIV serology and if HIV-positive, the samples were tested for viral load and antiretrovirals (ARV). For participants &lt;18 months TNA PCR is performed. We computed weighted proportions with 95% confidence intervals (CI), accounting for the complex survey design. We used bivariable and multivariable logistic regression to assess factors associated with HIV prevalence. Separate survey weights were developed for interview responses and for biomarker testing to account for the survey design and non-response. HIV burden was estimated by multiplying HIV prevalence by the national population projection by age for 2018. Of 9072 survey participants (&lt; 15 years), 87% (7865) had blood drawn with valid HIV test results. KENPHIA identified 57 HIV-positive children, translating to an HIV prevalence of 0.7%, (95% CI: 0.4%-1.0%) and an estimated 138,900 (95% CI: 84,000-193,800) of HIV among children in Kenya. Specifically, children who were orphaned had about 2 times higher odds of HIV-infection compared to those not orphaned, adjusted Odds Ratio (aOR) 2.2 (95% CI:1.0-4.8). Additionally, children whose caregivers had no knowledge of their HIV status also had 2 times higher odds of HIV-infection compared to whose caregivers had knowledge of their HIV status, aOR 2.4 (95% CI: 1.1-5.4)". From the unconditional analysis; population level estimates, 78.9% of HIV-positive children had known HIV status (95% CI: 67.1%-90.2%), 73.6% (95% CI: 60.9%-86.2%) were receiving ART, and 49% (95% CI: 32.1%-66.7%) were virally suppressed. However, in the clinical cascade for HIV infected children, 92% (95% CI: 84.4%-100%) were receiving ART, and of these, 67.1% (95% CI: 45.1%-89.2%) were virally suppressed. The KENPHIA survey confirms a substantial HIV burden among children in Kenya, especially among orphans.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0277613</identifier><language>eng</language><publisher>Public Library of Science (PLoS)</publisher><ispartof>PloS one, 2022-11, Vol.17 (11), p.e0277613</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Immaculate Mutisya</creatorcontrib><creatorcontrib>Evelyn Muthoni</creatorcontrib><creatorcontrib>Raphael O Ondondo</creatorcontrib><creatorcontrib>Jacques Muthusi</creatorcontrib><creatorcontrib>Lennah Omoto</creatorcontrib><creatorcontrib>Charlotte Pahe</creatorcontrib><creatorcontrib>Abraham Katana</creatorcontrib><creatorcontrib>Evelyn Ngugi</creatorcontrib><creatorcontrib>Kenneth Masamaro</creatorcontrib><creatorcontrib>Leonard Kingwara</creatorcontrib><creatorcontrib>Trudy Dobbs</creatorcontrib><creatorcontrib>Megan Bronson</creatorcontrib><creatorcontrib>Hetal K Patel</creatorcontrib><creatorcontrib>Nicholas Sewe</creatorcontrib><creatorcontrib>Doris Naitore</creatorcontrib><creatorcontrib>Kevin De Cock</creatorcontrib><creatorcontrib>Catherine Ngugi</creatorcontrib><creatorcontrib>Lucy Nganga</creatorcontrib><title>A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)</title><title>PloS one</title><description>We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors, and describe the clinical cascade among children aged &lt; 15 years in Kenya. Interviewers collected information from caregivers or guardians on child's demographics, HIV testing, and treatment history. Blood specimens were collected for HIV serology and if HIV-positive, the samples were tested for viral load and antiretrovirals (ARV). For participants &lt;18 months TNA PCR is performed. We computed weighted proportions with 95% confidence intervals (CI), accounting for the complex survey design. We used bivariable and multivariable logistic regression to assess factors associated with HIV prevalence. Separate survey weights were developed for interview responses and for biomarker testing to account for the survey design and non-response. HIV burden was estimated by multiplying HIV prevalence by the national population projection by age for 2018. Of 9072 survey participants (&lt; 15 years), 87% (7865) had blood drawn with valid HIV test results. KENPHIA identified 57 HIV-positive children, translating to an HIV prevalence of 0.7%, (95% CI: 0.4%-1.0%) and an estimated 138,900 (95% CI: 84,000-193,800) of HIV among children in Kenya. Specifically, children who were orphaned had about 2 times higher odds of HIV-infection compared to those not orphaned, adjusted Odds Ratio (aOR) 2.2 (95% CI:1.0-4.8). Additionally, children whose caregivers had no knowledge of their HIV status also had 2 times higher odds of HIV-infection compared to whose caregivers had knowledge of their HIV status, aOR 2.4 (95% CI: 1.1-5.4)". From the unconditional analysis; population level estimates, 78.9% of HIV-positive children had known HIV status (95% CI: 67.1%-90.2%), 73.6% (95% CI: 60.9%-86.2%) were receiving ART, and 49% (95% CI: 32.1%-66.7%) were virally suppressed. However, in the clinical cascade for HIV infected children, 92% (95% CI: 84.4%-100%) were receiving ART, and of these, 67.1% (95% CI: 45.1%-89.2%) were virally suppressed. The KENPHIA survey confirms a substantial HIV burden among children in Kenya, especially among orphans.</description><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNotjEtOwzAURS0kJEphBwzeEAYp_iT-DKuKT0UlJsA0erGd1lVqV05bKUtgH6yMlRABoysdnXMJuWF0xoRi99t0zBG72T5FP6NcKcnEGZkwI3ghORUX5LLvt5RWQks5IXkOEQ8hjQls0rH3m9Q56I_55AdIEZ6XH7DP_oSdj9YDRge2CzHY0bfYW3Qj3KW4BrsJncs-Aq69g-_PL1bB4DH3ECK8-Dgg3HLK9N0VOW-x6_31_07J--PD2-K5WL0-LRfzVeEY5ayQyNqmkUoLaZWjvOG0KUttjTKiYlQyJilrneVGoGtQYouae6O0paNhKzEly79fl3Bb73PYYR7qhKH-BSmva8yHYDtfK64EotBVJWzJRduUpjLO29IZ7h1F8QMlPmm2</recordid><startdate>20221123</startdate><enddate>20221123</enddate><creator>Immaculate Mutisya</creator><creator>Evelyn Muthoni</creator><creator>Raphael O Ondondo</creator><creator>Jacques Muthusi</creator><creator>Lennah Omoto</creator><creator>Charlotte Pahe</creator><creator>Abraham Katana</creator><creator>Evelyn Ngugi</creator><creator>Kenneth Masamaro</creator><creator>Leonard Kingwara</creator><creator>Trudy Dobbs</creator><creator>Megan Bronson</creator><creator>Hetal K Patel</creator><creator>Nicholas Sewe</creator><creator>Doris Naitore</creator><creator>Kevin De Cock</creator><creator>Catherine Ngugi</creator><creator>Lucy Nganga</creator><general>Public Library of Science (PLoS)</general><scope>DOA</scope></search><sort><creationdate>20221123</creationdate><title>A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)</title><author>Immaculate Mutisya ; Evelyn Muthoni ; Raphael O Ondondo ; Jacques Muthusi ; Lennah Omoto ; Charlotte Pahe ; Abraham Katana ; Evelyn Ngugi ; Kenneth Masamaro ; Leonard Kingwara ; Trudy Dobbs ; Megan Bronson ; Hetal K Patel ; Nicholas Sewe ; Doris Naitore ; Kevin De Cock ; Catherine Ngugi ; Lucy Nganga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d1021-6a1fbb67836c7d02b20b448c9793510611601fdc293adba6afa82e978c0793c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Immaculate Mutisya</creatorcontrib><creatorcontrib>Evelyn Muthoni</creatorcontrib><creatorcontrib>Raphael O Ondondo</creatorcontrib><creatorcontrib>Jacques Muthusi</creatorcontrib><creatorcontrib>Lennah Omoto</creatorcontrib><creatorcontrib>Charlotte Pahe</creatorcontrib><creatorcontrib>Abraham Katana</creatorcontrib><creatorcontrib>Evelyn Ngugi</creatorcontrib><creatorcontrib>Kenneth Masamaro</creatorcontrib><creatorcontrib>Leonard Kingwara</creatorcontrib><creatorcontrib>Trudy Dobbs</creatorcontrib><creatorcontrib>Megan Bronson</creatorcontrib><creatorcontrib>Hetal K Patel</creatorcontrib><creatorcontrib>Nicholas Sewe</creatorcontrib><creatorcontrib>Doris Naitore</creatorcontrib><creatorcontrib>Kevin De Cock</creatorcontrib><creatorcontrib>Catherine Ngugi</creatorcontrib><creatorcontrib>Lucy Nganga</creatorcontrib><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Immaculate Mutisya</au><au>Evelyn Muthoni</au><au>Raphael O Ondondo</au><au>Jacques Muthusi</au><au>Lennah Omoto</au><au>Charlotte Pahe</au><au>Abraham Katana</au><au>Evelyn Ngugi</au><au>Kenneth Masamaro</au><au>Leonard Kingwara</au><au>Trudy Dobbs</au><au>Megan Bronson</au><au>Hetal K Patel</au><au>Nicholas Sewe</au><au>Doris Naitore</au><au>Kevin De Cock</au><au>Catherine Ngugi</au><au>Lucy Nganga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)</atitle><jtitle>PloS one</jtitle><date>2022-11-23</date><risdate>2022</risdate><volume>17</volume><issue>11</issue><spage>e0277613</spage><pages>e0277613-</pages><eissn>1932-6203</eissn><abstract>We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors, and describe the clinical cascade among children aged &lt; 15 years in Kenya. Interviewers collected information from caregivers or guardians on child's demographics, HIV testing, and treatment history. Blood specimens were collected for HIV serology and if HIV-positive, the samples were tested for viral load and antiretrovirals (ARV). For participants &lt;18 months TNA PCR is performed. We computed weighted proportions with 95% confidence intervals (CI), accounting for the complex survey design. We used bivariable and multivariable logistic regression to assess factors associated with HIV prevalence. Separate survey weights were developed for interview responses and for biomarker testing to account for the survey design and non-response. HIV burden was estimated by multiplying HIV prevalence by the national population projection by age for 2018. Of 9072 survey participants (&lt; 15 years), 87% (7865) had blood drawn with valid HIV test results. KENPHIA identified 57 HIV-positive children, translating to an HIV prevalence of 0.7%, (95% CI: 0.4%-1.0%) and an estimated 138,900 (95% CI: 84,000-193,800) of HIV among children in Kenya. Specifically, children who were orphaned had about 2 times higher odds of HIV-infection compared to those not orphaned, adjusted Odds Ratio (aOR) 2.2 (95% CI:1.0-4.8). Additionally, children whose caregivers had no knowledge of their HIV status also had 2 times higher odds of HIV-infection compared to whose caregivers had knowledge of their HIV status, aOR 2.4 (95% CI: 1.1-5.4)". From the unconditional analysis; population level estimates, 78.9% of HIV-positive children had known HIV status (95% CI: 67.1%-90.2%), 73.6% (95% CI: 60.9%-86.2%) were receiving ART, and 49% (95% CI: 32.1%-66.7%) were virally suppressed. However, in the clinical cascade for HIV infected children, 92% (95% CI: 84.4%-100%) were receiving ART, and of these, 67.1% (95% CI: 45.1%-89.2%) were virally suppressed. The KENPHIA survey confirms a substantial HIV burden among children in Kenya, especially among orphans.</abstract><pub>Public Library of Science (PLoS)</pub><doi>10.1371/journal.pone.0277613</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier EISSN: 1932-6203
ispartof PloS one, 2022-11, Vol.17 (11), p.e0277613
issn 1932-6203
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_7273aa38553c423fb4959dec4d92ed0a
source Access via ProQuest (Open Access); PubMed Central
title A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T06%3A13%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-doaj&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20national%20household%20survey%20on%20HIV%20prevalence%20and%20clinical%20cascade%20among%20children%20aged%20%E2%89%A415%20years%20in%20Kenya%20(2018)&rft.jtitle=PloS%20one&rft.au=Immaculate%20Mutisya&rft.date=2022-11-23&rft.volume=17&rft.issue=11&rft.spage=e0277613&rft.pages=e0277613-&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0277613&rft_dat=%3Cdoaj%3Eoai_doaj_org_article_7273aa38553c423fb4959dec4d92ed0a%3C/doaj%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-d1021-6a1fbb67836c7d02b20b448c9793510611601fdc293adba6afa82e978c0793c53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true