Ti3C2 Nanosheets Functionalized with Ferritin–Biomimetic Platinum Nanoparticles for Electrochemical Biosensors of Nitrite

Nitrites widely exist in human life and the natural environment, but excessive contents of nitrites will result in adverse effects on the environment and human health; hence, sensitive and stable nitrite detection systems are needed. In this study, we report the synthesis of Ti3C2 nanosheets functio...

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Bibliographic Details
Published in:Biosensors (Basel) 2024-05, Vol.14 (5), p.258
Main Authors: Mu, Rongqiu, Zhu, Danzhu, Wei, Gang
Format: Article
Language:English
Subjects:
Acids
Apoferritin
Biochemistry
Biocompatibility
Biomimetic materials
Biomimetics
Biosensors
Composite materials
electrochemical biosensor
Electrochemistry
Electrodes
Environmental effects
Ferritin
Liver cancer
Lungs
Mineralization
NaNO2
Nanomaterials
Nanoparticles
Nanosheets
Natural environment
Nitrites
Oxidation
Platinum
platinum nanoparticles
Poisoning
Proteins
Sodium nitrite
Ti3C2 nanosheets
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Summary:Nitrites widely exist in human life and the natural environment, but excessive contents of nitrites will result in adverse effects on the environment and human health; hence, sensitive and stable nitrite detection systems are needed. In this study, we report the synthesis of Ti3C2 nanosheets functionalized with apoferritin (ApoF)–biomimetic platinum (Pt) nanoparticle (Pt@ApoF/Ti3C2) composite materials, which were formed by using ApoF as a template and protein-inspired biomineralization. The formed nanohybrid exhibits excellent electrochemical sensing performance towards nitrite (NaNO2). Specifically, the Pt@ApoF catalyzes the conversion of nitrites into nitrates, converting the chemical signal into an electrical signal. The prepared Pt@ApoF/Ti3C2-based electrochemical NaNO2 biosensors demonstrate a wide detection range of 0.001–9 mM with a low detection limit of 0.425 μM. Additionally, the biosensors possess high selectivity and sensitivity while maintaining a relatively stable electrochemical sensing performance within 7 days, enabling the monitoring of NaNO2 in complex environments. The successful preparation of the Pt@ApoF/Ti3C2 nanohybrid materials provides a new approach for constructing efficient electrochemical biosensors, offering a simple and rapid method for detecting NaNO2 in complex environments.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios14050258